辐射对中耳黏膜的急性影响。

Acute effects of irradiation on middle ear mucosa.

作者信息

Ohashi Y, Nakai Y, Esaki Y, Ikeoka H, Koshimo H, Onoyama Y

机构信息

Department of Otolaryngology, Osaka City University Medical School, Japan.

出版信息

Ann Otol Rhinol Laryngol. 1988 Mar-Apr;97(2 Pt 1):173-8. doi: 10.1177/000348948809700215.

DOI:10.1177/000348948809700215

PMID:3355045

Abstract

Single field, fixed irradiation of bilateral tympanic cavities using 200-kV x-rays was administered to five guinea pigs. The irradiation dose was 30 Gy. They were killed immediately after irradiation, and bilateral middle ear mucosa was examined for ciliary activity and epithelial structure. Significant deterioration of the ciliary activity in the middle ear mucosa was observed, proximal as well as distal to the eustachian tube. Electron microscopy showed various changes in the irradiated middle ear mucosa. The most conspicuous findings were hyperreactivity in secretion, vacuolation of ciliated cells, and stomal edema.

摘要

对5只豚鼠使用200千伏X射线对双侧鼓室进行单野、固定照射。照射剂量为30戈瑞。照射后立即处死动物，检查双侧中耳黏膜的纤毛活性和上皮结构。观察到咽鼓管近端和远端的中耳黏膜纤毛活性显著下降。电子显微镜检查显示照射后的中耳黏膜有各种变化。最明显的发现是分泌反应亢进、纤毛细胞空泡化和间质水肿。