辐射对咽鼓管及中耳黏膜纤毛活动的影响。

Effects of irradiation on the ciliary activity of the eustachian tube and the middle ear mucosa.

作者信息

Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Onoyama Y

出版信息

Arch Otorhinolaryngol. 1985;242(3):343-8. doi: 10.1007/BF00453560.

Abstract

Radiation-induced changes in the ciliary activity of the eustachian tube and middle ear mucosa were investigated in a laboratory model. Twenty-four guinea pigs were sacrificed, and a mucosa at the bony portion of each eustachian tube and from the middle ear proximal and distal to the tube were sampled. The mucosal samples were irradiated with 200 kV hard X-rays discretely at a dosage level of 0.5-30.0 Gy, and the induced changes in ciliary activity were expressed as a percent deviation from baseline levels before irradiation. The present study demonstrates that the cilia of the eustachian tube and middle ear mucosa show different reactions to irradiation according to their tympanic locations.

摘要

在实验室模型中研究了辐射引起的咽鼓管和中耳黏膜纤毛活动的变化。处死24只豚鼠，采集每个咽鼓管骨部以及中耳在咽鼓管近端和远端的黏膜样本。对黏膜样本分别用200 kV硬X射线以0.5 - 30.0 Gy的剂量水平进行照射，纤毛活动的诱导变化表示为相对于照射前基线水平的百分比偏差。本研究表明，咽鼓管和中耳黏膜的纤毛根据其鼓室位置对辐射表现出不同的反应。