Child Language Doctoral Program, University of Kansas, 1000 Sunnyside Ave, Lawrence, KS, 66045, USA.
The Life Span Institute, University of Kansas, Lawrence, KS, USA.
J Autism Dev Disord. 2021 Dec;51(12):4520-4533. doi: 10.1007/s10803-021-04892-2. Epub 2021 Feb 6.
Accurate representation of autism spectrum disorder (ASD) in fragile X syndrome (FXS) is necessary for the field. We examined classifications of ASD using three approaches-Autism Diagnostic Observation Schedule (ADOS-2; Lord et al. 2012), Childhood Autism Rating Scale (CARS2-ST; Schopler et al. 2010), and Vineland Adaptive Behavior Scales (VABS-II; Sparrow et al. 2005)-in 45 adolescents with FXS. Maladaptive items from the VABS-II plus a maternal interview were matched with Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association 2013) criteria for ASD. Results indicated discrepant classifications. The ADOS-2 yielded the highest rate of comorbid autism (71%); CARS2-ST and VABS-II/DSM-5 yielded lower rates (38% and 42%, respectively). A singular measure of autism symptomology is insufficient to characterize autism in FXS.
准确描述脆性 X 综合征（FXS）中的自闭症谱系障碍（ASD）对于该领域至关重要。我们使用三种方法（自闭症诊断观察量表（ADOS-2；Lord 等人，2012 年）、儿童自闭症评定量表（CARS2-ST；Schopler 等人，2010 年）和韦氏儿童智力量表（第三版）（VABS-II；Sparrow 等人，2005 年））来评估 45 名 FXS 青少年的 ASD 分类。VABS-II 的不适应项目加上母亲访谈与精神疾病诊断与统计手册，第五版（DSM-5；美国精神病学协会，2013 年）的 ASD 标准相匹配。结果表明分类存在差异。ADOS-2 得出的自闭症共病率最高（71%）；CARS2-ST 和 VABS-II/DSM-5 的比率较低（分别为 38%和 42%）。单一的自闭症症状测量不足以描述 FXS 中的自闭症。
