脆性X综合征男孩的自闭症症状学：与非综合征性自闭症谱系障碍的横断面发育轨迹比较
Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder.
作者信息
Thurman Angela John, McDuffie Andrea, Kover Sara T, Hagerman Randi J, Abbeduto Leonard
机构信息
MIND Institute, University of California Davis, 2825 50th Street, Room 2101, Sacramento, CA, 95817, USA,
出版信息
J Autism Dev Disord. 2015 Sep;45(9):2816-32. doi: 10.1007/s10803-015-2443-4.
Abstract
Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.
摘要
尽管患有脆性X综合征（FXS）的男性常被描述为表现出自闭症症状，但关于代表自闭症核心领域的行为症状是由相同还是不同的潜在神经/心理机制导致，仍存在诸多争议。本研究采用横断面发展轨迹方法，比较了脆性X综合征患者与非综合征性自闭症患者在自闭症症状方面相对于实际年龄（CA）、非言语智商和表达性词汇能力的概况。结果表明，与非综合征性自闭症男性相比，脆性X综合征男性自闭症症状的出现及其发展轨迹在重要方面因实际年龄、非言语认知能力和表达性词汇的不同而有所差异。文中讨论了其理论和临床意义。
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