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JAB1 的过表达促进食管鳞癌的恶性行为并预测不良预后。

Overexpression of JAB1 promotes malignant behavior and predicts poor prognosis in esophageal squamous cell carcinoma.

机构信息

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

出版信息

Thorac Cancer. 2020 Apr;11(4):973-982. doi: 10.1111/1759-7714.13350. Epub 2020 Feb 16.

DOI:10.1111/1759-7714.13350
PMID:32064781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7113044/
Abstract

BACKGROUND

This study investigated the expression and biological function of JAB1 in esophageal squamous cell carcinoma (ESCC).

METHODS

The expression of JAB1 in ESCC tissues and cells was measured using reverse transcriptase-polymerase chain reaction (RT-PCR), immunohistochemistry (IHC), and western blot analysis. Kaplan-Meier survival analysis was performed to explore the effect of JAB1 expression on the prognosis of ESCC patients. Furthermore, experiments were conducted in vivo and in vitro to determine the effect of JAB1 expression on the malignant behavior of ESCC cells.

RESULTS

Compared with adjacent tissues, JAB1 was highly overexpressed in cancer tissues (P = 0.01). Univariate and multivariate analyses of clinical data indicated that patients with JAB1 overexpression had a worse prognosis (P = 0.001 and P = 0.049, respectively). Cell function experiments and tumorigenesis experiments in nude mice showed that the upregulation of JAB1 might promote malignant behavior, and vice versa.

CONCLUSIONS

Overexpression of JAB1 promoted the proliferation, migration, and invasion of ESCC cells, and was significantly associated with poor prognosis of ESCC patients. Therefore, JAB1 could be considered as a promising prognostic factor and a possible target for the specific therapy of ESCC.

KEY POINTS

In this study, we found that JAB1 was highly overexpressed in cancer tissues, which could influence the malignant behavior of ESCC cells, and was significantly associated with poor prognosis of ESCC patients.

摘要

背景

本研究旨在探讨 Jab1 在食管鳞状细胞癌（ESCC）中的表达和生物学功能。

方法

采用逆转录-聚合酶链反应（RT-PCR）、免疫组织化学（IHC）和 Western blot 分析检测 Jab1 在 ESCC 组织和细胞中的表达。通过 Kaplan-Meier 生存分析探讨 Jab1 表达对 ESCC 患者预后的影响。此外，还进行了体内和体外实验，以确定 Jab1 表达对 ESCC 细胞恶性行为的影响。

结果

与相邻组织相比，Jab1 在癌组织中高度过表达（P = 0.01）。临床数据分析的单因素和多因素分析表明，Jab1 过表达的患者预后较差（P = 0.001 和 P = 0.049）。细胞功能实验和裸鼠肿瘤生成实验表明，Jab1 的上调可能促进恶性行为，反之亦然。

结论

Jab1 的过表达促进了 ESCC 细胞的增殖、迁移和侵袭，与 ESCC 患者的不良预后显著相关。因此，Jab1 可以被视为一个有前途的预后因素和 ESCC 特异性治疗的可能靶点。

关键要点

在本研究中，我们发现 Jab1 在癌组织中高度过表达，这可能影响 ESCC 细胞的恶性行为，并与 ESCC 患者的不良预后显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/e5b58077482e/TCA-11-973-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/8b723486cf69/TCA-11-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/bb2ad9d1ba14/TCA-11-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/5d67c19eb107/TCA-11-973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/e5b58077482e/TCA-11-973-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/8b723486cf69/TCA-11-973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/bb2ad9d1ba14/TCA-11-973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/5d67c19eb107/TCA-11-973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/212b/7113044/e5b58077482e/TCA-11-973-g004.jpg

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