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身高家族相似性中可遗传和不可遗传成分的年龄趋势。

Age trends in transmissible and non-transmissible components of family resemblance for stature.

作者信息

Byard P J, Siervogel R M, Roche A F

机构信息

Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio.

出版信息

Ann Hum Biol. 1988 Mar-Apr;15(2):111-8. doi: 10.1080/03014468800009531.

Abstract

Yearly measurements of recumbent length and stature on participants in the Fels Longitudinal Study of Growth and their first-degree relatives were submitted to path analysis. Using a model consistent with simple polygenic inheritance, two parameters were estimated at each age: t2 or transmissibility, and s, or non-transmissible sibling resemblance. Transmissibility showed no long-term age trends, whereas non-transmissible sibling resemblance declined steadily from age four years to the late teens. The factors controlling family resemblance for stature (genes and common family environment) make different contributions at different points in the growth cycle of these family members. These differences are more discernable in the Fels data because all family members, including parents, are measured at the same age throughout childhood.

摘要

对参加费尔斯生长纵向研究的参与者及其一级亲属进行了每年一次的卧姿身长和身高测量,并将其提交给路径分析。使用与简单多基因遗传一致的模型,在每个年龄估计两个参数:t2或传递性,以及s或非传递性同胞相似性。传递性没有长期的年龄趋势,而非传递性同胞相似性从4岁到青少年后期稳步下降。控制身高家族相似性的因素(基因和共同的家庭环境)在这些家庭成员生长周期的不同阶段做出不同的贡献。在费尔斯的数据中,这些差异更明显,因为所有家庭成员,包括父母,在整个童年时期都是在相同年龄进行测量的。

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