Huang Hui, Shen Hongxian, Ning Kui, Zhang Ruiling, Sun Wei, Li Bing, Jiang Haifeng, Wang Wenzheng, Du Jiang, Zhao Min, Yi Zhihua, Li Jing, Zhu Rongxin, Lu Shuiping, Xie Shiping, Wang Xiaoping, Fu Wei, Gao Chengge, Hao Wei
Affiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Front Psychiatry. 2021 Jan 22;11:627338. doi: 10.3389/fpsyt.2020.627338. eCollection 2020.
Alcohol use disorder (AUD) is a serious issue worldwide and frequently co-occurs with depression. However, the quality of life (QOL) of AUD patients with and without depression is not well studied in the Chinese Han population. The aim of this study was to investigate QOL and its correlates in AUD patients with and without depression in China. Five hundred and fifteen psychiatric patients diagnosed with AUD were recruited. All these patients completed the Beck Depression Inventory (BDI) to assess depression, the Medical Outcome Study 36-Item Short Form Health Survey (SF-36) to evaluate QOL and the Alcohol Use Disorders Identification Test (AUDIT) to measure the severity of drinking. Compared with AUD patients without depression, those with depression had a lower QOL in all eight domains of the SF-36 (all < 0.001), but were more willing to have alcohol-related treatment ( < 0.05). Negative correlations were noted between (i) the BDI total score and all eight domains of the SF-36 (all < 0.001); and (ii) between the AUDIT total score and six domains of the SF-36 (all < 0.05). Depression impairs QOL in patients with AUD in China. Early intervention in comorbid depression to improve QOL is needed.
酒精使用障碍（AUD）是一个全球性的严重问题，且常与抑郁症并发。然而，在中国汉族人群中，合并或未合并抑郁症的AUD患者的生活质量（QOL）尚未得到充分研究。本研究的目的是调查中国合并或未合并抑郁症的AUD患者的生活质量及其相关因素。招募了515名被诊断为AUD的精神科患者。所有这些患者都完成了贝克抑郁量表（BDI）以评估抑郁程度、医学结局研究简明健康调查36项量表（SF - 36）以评估生活质量，以及酒精使用障碍识别测试（AUDIT）以测量饮酒严重程度。与未合并抑郁症的AUD患者相比，合并抑郁症的患者在SF - 36的所有八个领域的生活质量较低（均<0.001），但更愿意接受与酒精相关的治疗（<0.05）。观察到：（i）BDI总分与SF - 36的所有八个领域之间存在负相关（均<0.001）；（ii）AUDIT总分与SF - 36的六个领域之间存在负相关（均<0.05）。在中国，抑郁症会损害AUD患者的生活质量。需要对共病抑郁症进行早期干预以改善生活质量。
