Shu Che-Chi, Chen Wan-Ci, Chang Yao-Duo, Chen Jyy-Ning, Liu Feng-You, Huang Yu-Shan, You Chao-Xuan, Wu En Hsuan
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan.
Front Microbiol. 2021 Jan 20;11:580466. doi: 10.3389/fmicb.2020.580466. eCollection 2020.
The vancomycin-resistant Enterococci (VRE) have progressively become a severe medical problem. Although clinics have started to reduce vancomycin prescription, vancomycin resistance has not been contained. We found that the transfer of vancomycin resistance in increased more than 30-fold upon treatment by streptomycin. Notably, treatment with an antibiotic caused the bacteria to become resistant to another. The response was even stronger in the well-studied plasmid pCF10 and the number of transconjugants increased about 100,000-fold. We tested four different antibiotics, and all of them induced conjugal response. Through a mathematical model based on gene regulation, we found a plausible explanation. quorum sensing, the change of the cell density triggers the conjugation. Moreover, we searched for generality and found a similar strategy in . The outcome of the present study suggests that even common antibiotics must not be overused.
耐万古霉素肠球菌（VRE）已逐渐成为一个严重的医学问题。尽管临床已开始减少万古霉素的处方用量，但万古霉素耐药性仍未得到控制。我们发现，经链霉素处理后，万古霉素耐药性的转移增加了30多倍。值得注意的是，用一种抗生素治疗会使细菌对另一种抗生素产生耐药性。在经过充分研究的质粒pCF10中，这种反应甚至更强，转接合子的数量增加了约10万倍。我们测试了四种不同的抗生素，它们都诱导了接合反应。通过基于基因调控的数学模型，我们找到了一个合理的解释。群体感应中，细胞密度的变化触发了接合作用。此外，我们寻找普遍性并在……中发现了类似的策略。本研究结果表明，即使是普通抗生素也绝不能过度使用。
