地中海贫血患者中去铁胺导致的微量元素缺乏及急性眼毒性
Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia.
作者信息
De Virgiliis S, Congia M, Turco M P, Frau F, Dessi C, Argiolu F, Sorcinelli R, Sitzia A, Cao A
机构信息
Istituto di Clinica e Biologia dell Età Evolutiva, Università Studi Cagliari, Sardinia, Italy.
出版信息
Arch Dis Child. 1988 Mar;63(3):250-5. doi: 10.1136/adc.63.3.250.
Abstract
High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high faecal iron, zinc, and copper excretion, and reduced granulocyte zinc concentrations and alkaline phosphatase activity. The retinal abnormalities may be related to the zinc and copper deficiency and/or iron depletion 'per se' which interferes negatively with critical iron dependent enzymes.
摘要
短期内静脉输注大剂量去铁胺可导致大量粪便和尿液铁排泄，但也会产生视网膜异常，其特征为视网膜电图振幅降低和暗适应缺陷。这种治疗方案还会导致粪便中铁、锌和铜的高排泄，以及粒细胞锌浓度降低和碱性磷酸酶活性降低。视网膜异常可能与锌和铜缺乏及/或铁缺乏本身有关，铁缺乏会对关键的铁依赖性酶产生负面影响。
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