Savage E P, Keefe T J, Mounce L M, Heaton R K, Lewis J A, Burcar P J
Department of Environmental Health, Colorado State University, Fort Collins.
Arch Environ Health. 1988 Jan-Feb;43(1):38-45. doi: 10.1080/00039896.1988.9934372.
To evaluate the latent neurological effects of organophosphate pesticide poisoning, this epidemiologic study examined 100 matched-pairs of individuals with previous acute organophosphate pesticide poisoning and nonpoisoned controls. No significant difference between poisoned subjects and controls was found on audiometric tests, ophthalmic tests, electroencephalograms, or the clinical serum and blood chemistry evaluations. Of the more than 50 scores from the neurological examination, abnormalities were demonstrated among the cases only on measures of memory, abstraction, and mood, and on one test of motor reflexes. Differences between the two cohorts were much more apparent in the neuropsychological tests. The differences occurred on tests of widely varying abilities including intellectual functioning, academic skills, abstraction and flexibility of thinking, and simple motor skills. Twice as many cases as controls (24 vs. 12) had Halstead-Reitan Battery summary scores in the range characteristic of individuals with cerebral damage or dysfunction. Results from the Minnesota Multiphasic Personality Inventory and the Patient's and Relative's Assessment of Patient Functioning Inventories also revealed greater distress and complaints of disability for the poisoned subjects.
为评估有机磷农药中毒的潜在神经学影响，这项流行病学研究对100对匹配个体进行了检查，其中一组为曾有急性有机磷农药中毒史的个体，另一组为未中毒的对照者。在听力测试、眼科检查、脑电图检查或临床血清及血液化学评估中，中毒受试者与对照者之间未发现显著差异。在神经学检查的50多项评分中，仅在记忆、抽象思维和情绪测量以及一项运动反射测试中，病例组出现了异常。两组之间的差异在神经心理学测试中更为明显。差异出现在各种能力的测试中，包括智力功能、学术技能、思维的抽象性和灵活性以及简单运动技能。病例组中哈雷特 - 雷顿神经心理成套测验总结得分处于脑损伤或功能障碍个体特征范围内的人数是对照组的两倍（24例对12例）。明尼苏达多相人格调查表以及患者及亲属对患者功能评估量表的结果也显示，中毒受试者有更大的痛苦和更多的残疾抱怨。
