Ames R G, Steenland K, Jenkins B, Chrislip D, Russo J
California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, Berkeley, USA.
Arch Environ Health. 1995 Nov-Dec;50(6):440-4. doi: 10.1080/00039896.1995.9935980.
To test the hypothesis that chronic neurologic sequelae are associated with cholinesterase depression short of frank organophosphate poisoning, we compared 45 male subjects who had a history of moderate cholinesterase inhibition with 90 male subjects who had neither past cholinesterase inhibition nor current pesticide exposure. Cholinesterase-inhibited subjects were defined as having had a history of (a) red blood cell cholinesterase at 70% or less of baseline or (b) plasma cholinesterase at 60% or less of baseline absent symptoms of frank poisoning. In the subject comparison evaluation, only 1 of 27 neurologic tests (i.e., serial digit performance) was significant statistically, but it was opposite of the direction hypothesized. In a companion study for which the same battery of neurologic tests and the same subjects were used, neurologic sequelae were related to high exposures among subjects who sought treatment for organophosphate poisoning. The data in the current study, in which the subjects experienced lower exposures short of frank poisoning, provide some evidence that preventing acute organophosphate poisoning also prevents neurologic sequelae.
为了验证慢性神经后遗症与未达到明显有机磷中毒程度的胆碱酯酶抑制有关这一假设，我们将45名有中度胆碱酯酶抑制病史的男性受试者与90名既无既往胆碱酯酶抑制史也无当前农药接触史的男性受试者进行了比较。胆碱酯酶受抑制的受试者被定义为有以下病史：(a) 红细胞胆碱酯酶为基线的70%或更低，或 (b) 血浆胆碱酯酶为基线的60%或更低且无明显中毒症状。在受试者比较评估中，27项神经学测试中只有1项（即连续数字表现）具有统计学意义，但与假设的方向相反。在一项配套研究中，使用了相同的神经学测试组合和相同的受试者，神经后遗症与寻求有机磷中毒治疗的受试者中的高暴露有关。在本研究中，受试者经历的暴露程度低于明显中毒，数据提供了一些证据表明预防急性有机磷中毒也能预防神经后遗症。
