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免疫功能正常个体的化脓性心包炎

purulent pericarditis in an immunocompetent individual.

作者信息

Shah Smit, Shah Pooja, Green Jared

机构信息

Tower Health System, Reading Hospital, Reading, PA, USA.

出版信息

J Community Hosp Intern Med Perspect. 2021 Jan 26;11(1):96-98. doi: 10.1080/20009666.2020.1835213.

Abstract

Purulent pericarditis is a rare bacterial illness in the post-antibiotic era that is defined as pericardial infection with gross or microscopic purulence in the pericardium. Common causes include nosocomial bloodstream infections, direct spread through thoracic surgery, or immunosuppression. We present a case of a 66-year-old male with a history of mantle cell lymphoma status post chemotherapy, completed about 4 years before presentation, in general, good health presented with acute typical chest pain associated with dyspnea on exertion. 12-lead EKG demonstrated ST elevations in anterolateral and lateral leads. Patient was initially being managed as Acute Coronary Syndrome, though, preliminary bedside echocardiogram demonstrated a large pericardial effusion with pretamponade physiology, which was confirmed with a STAT transthoracic echocardiogram. He underwent an emergent pericardial window which drained 350-400 ml of yellow murky pericardial fluid. Blood cultures and pericardial fluid cultures grew Haemophilus (H. ). Upon further history taking, patient revealed experiencing upper respiratory symptoms and being diagnosed with pansinusitis 2 months before his admission. He was treated with IV ceftriaxone for 4 weeks from the day of negative blood cultures. H. upper respiratory infection is usually seen in the unvaccinated pediatric population, or in immunocompromised individuals; however, few cases in vaccinated adults have been reported, as in the above case. Sequalae from H. infection is usually limited to upper respiratory symptoms and mastoiditis, but rarely, pericarditis could occur. It is important to include pericarditis in the differential for chest pain in a patient with a recent history of upper respiratory symptoms. Pericarditis is a rare but potentially serious complication of recent upper respiratory tract infection, and needs to be promptly identified and treated to avoid further morbidity.

摘要

脓性心包炎是抗生素时代后的一种罕见细菌性疾病,定义为心包感染伴心包内肉眼可见或显微镜下可见的脓性渗出物。常见病因包括医院获得性血流感染、经胸外科手术直接蔓延或免疫抑制。我们报告一例66岁男性病例,该患者有套细胞淋巴瘤病史,化疗结束于就诊前约4年,总体健康状况良好,现出现与劳力性呼吸困难相关的急性典型胸痛。12导联心电图显示前侧壁和侧壁导联ST段抬高。患者最初被按照急性冠状动脉综合征进行处理,然而,床旁初步超声心动图显示大量心包积液伴心包填塞前期生理表现,经急诊经胸超声心动图证实。他接受了紧急心包开窗引流术,引出350 - 400毫升黄色浑浊心包积液。血培养和心包积液培养均培养出嗜血杆菌。进一步询问病史时,患者透露在入院前2个月出现上呼吸道症状并被诊断为全鼻窦炎。自血培养阴性之日起,他接受了4周的静脉注射头孢曲松治疗。嗜血杆菌引起的上呼吸道感染通常见于未接种疫苗的儿童人群或免疫功能低下者;然而,如上述病例所示,接种疫苗的成年人中也有少数病例报告。嗜血杆菌感染的后遗症通常局限于上呼吸道症状和乳突炎,但很少会发生心包炎。对于近期有上呼吸道症状的胸痛患者,在鉴别诊断中考虑心包炎很重要。心包炎是近期上呼吸道感染罕见但可能严重的并发症,需要及时识别和治疗以避免进一步发病。

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