Liang Shiwei, Cao Huijun, Ying Fei, Zhang Chenchen
Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.
School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People's Republic of China.
Infect Drug Resist. 2022 Aug 22;15:4749-4757. doi: 10.2147/IDR.S379654. eCollection 2022.
The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.
该报告描述了一名44岁女性患者，她死于由肺炎克雷伯菌（KP）引起的罕见急性化脓性心包炎。基因组分析从五株分离菌（血培养、尿液、腹水、心包积液和痰液）中鉴定出一株广泛耐药的ST11-K64肺炎克雷伯菌菌株。在心包积液分离菌中鉴定出了几个高毒力（hv）和耐碳青霉烯（CR）基因。这些分离菌对健康人血清显示出低抗性。本研究强调了CR-hvKP感染在患有潜在合并症（如糖尿病和慢性疾病）的患者中的潜在致死性。
