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成人免疫性血小板减少症不断发展的治疗方式

Evolving treatment modalities for immune thrombocytopenia in adults.

作者信息

Khadka Sushmita, Kasireddy Vineela, Dhakal Pravash Kumar, Dadiboyina Chandrakala

机构信息

Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, PA, USA.

出版信息

J Community Hosp Intern Med Perspect. 2021 Jan 26;11(1):115-119. doi: 10.1080/20009666.2020.1843237.

DOI:10.1080/20009666.2020.1843237
PMID:33552432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7850435/
Abstract

The management of patients with relapsed or refractory immune thrombocytopenia (ITP) remains challenging for hematologists. While there are a multitude of drugs available, it is largely an individualized management based on patient preferences, side effects, previous treatment received, and responses to them, comorbidities and cost associated with the treatment. We hereby review the newer approaches in the treatment of ITP.

摘要

对于血液科医生而言,复发或难治性免疫性血小板减少症(ITP)患者的管理仍然具有挑战性。虽然有多种药物可供使用,但很大程度上是基于患者的偏好、副作用、既往接受的治疗及其反应、合并症以及治疗相关费用进行个体化管理。我们在此回顾ITP治疗的新方法。

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本文引用的文献

1
DNA methylation plays an important role in immune thrombocytopenia.DNA 甲基化在免疫性血小板减少症中发挥重要作用。
Int Immunopharmacol. 2020 Jun;83:106390. doi: 10.1016/j.intimp.2020.106390. Epub 2020 Mar 16.
2
Combination of thrombopoietin receptor agonists, immunosuppressants and intravenous immunoglobulin as treatment of severe refractory immune thrombocytopenia in adults and children.血小板生成素受体激动剂、免疫抑制剂和静脉注射免疫球蛋白联合治疗成人和儿童严重难治性免疫性血小板减少症。
Br J Haematol. 2020 Apr;189(2):e37-e40. doi: 10.1111/bjh.16426. Epub 2020 Feb 24.
3
American Society of Hematology 2019 guidelines for immune thrombocytopenia.美国血液学会 2019 年免疫性血小板减少症治疗指南。
Blood Adv. 2019 Dec 10;3(23):3829-3866. doi: 10.1182/bloodadvances.2019000966.
4
A prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia.一项关于低剂量地西他滨治疗成人难治性免疫性血小板减少症的前瞻性、多中心研究。
Am J Hematol. 2019 Dec;94(12):1374-1381. doi: 10.1002/ajh.25646. Epub 2019 Oct 17.
5
Platelet and peripheral white blood cell counts at diagnosis predict the response of adult immune thrombocytopenia to recombinant human interleukin-11: A retrospective, single-center, case-control study.诊断时的血小板和外周血白细胞计数可预测成人免疫性血小板减少症对重组人白细胞介素-11的反应:一项回顾性、单中心、病例对照研究。
Medicine (Baltimore). 2019 Apr;98(16):e15195. doi: 10.1097/MD.0000000000015195.
6
Glucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series.糖皮质激素促进难治性 ITP 对血小板生成素受体激动剂的反应:病例系列。
Int J Hematol. 2019 Aug;110(2):255-259. doi: 10.1007/s12185-019-02638-6. Epub 2019 Apr 10.
7
Cost-consequence model comparing eltrombopag and romiplostim in pediatric patients with chronic immune thrombocytopenia.比较艾曲泊帕和罗米司亭治疗儿童慢性免疫性血小板减少症的成本-后果模型
Clinicoecon Outcomes Res. 2018 Nov 5;10:715-721. doi: 10.2147/CEOR.S177338. eCollection 2018.
8
Proteasome Inhibition with Bortezomib Induces Apoptosis of Long-Lived Plasma Cells in Steroid-Resistant or Relapsed Immune Thrombocytopaenia.硼替佐米抑制蛋白酶体诱导激素耐药或复发免疫性血小板减少症中长寿浆细胞凋亡。
Thromb Haemost. 2018 Oct;118(10):1752-1764. doi: 10.1055/s-0038-1669921. Epub 2018 Sep 20.
9
Current and evolving treatment strategies in adult immune thrombocytopenia.成人免疫性血小板减少症的当前及不断发展的治疗策略
Memo. 2018;11(3):241-246. doi: 10.1007/s12254-018-0428-7. Epub 2018 Aug 15.
10
Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia.三期随机研究avatrombopag,一种新型的促血小板生成素受体激动剂,用于治疗慢性免疫性血小板减少症。
Br J Haematol. 2018 Nov;183(3):479-490. doi: 10.1111/bjh.15573. Epub 2018 Sep 7.