Elkattawy Sherif, Alyacoub Ramez, Ejikeme Chidinma, Noori Muhammad Atif Masood, Remolina Carlos
Department of Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center Program, Elizabeth, NJ, USA.
Department of Internal Medicine, Division of Pulmonary and Critical Care, Trinitas Regional Medical Center, Elizabeth, NJ, USA.
J Community Hosp Intern Med Perspect. 2021 Jan 26;11(1):139-142. doi: 10.1080/20009666.2020.1854417.
Naloxone-induced noncardiogenic pulmonary edema is a rare but reported entity that can occur following naloxone use in the reversal of opioid overdose. Proposed mechanisms include an adrenergic crisis secondary to catecholamine surge which causes more volume shift to pulmonary vasculature, subsequently leading to pulmonary edema. It appears to be more common when higher doses of naloxone are used. We present a case of a patient with opioid overdose came with altered mental status developed early features of pulmonary edema following the administration of multiple doses of naloxone. She responded well with the administration of diuretics and oxygen supplementation. Her oxygen requirements improved and didn't require mechanical ventilation.
