Avelar Rodriguez David, Popov Jelena, Ratcliffe Elyanne M, Toro Monjaraz Erick Manuel
Department of Pediatric Gastroenterology and Nutrition, Instituto Nacional de Pediatría, Mexico City, Mexico.
Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Front Pediatr. 2021 Jan 20;8:595531. doi: 10.3389/fped.2020.595531. eCollection 2020.
Functional constipation is a common condition in childhood with significant impact on patients' quality of life and on health care resources. Functional constipation is characterized by decreased bowel movements and/or hard stools, which cause significant distress for children and their caregivers. While the term "functional" may imply the absence of organic causes with a focus on behavioral aspects, 40% of children continue to have symptoms beyond conventional management with one in four children continuing to experience constipation into adulthood. The refractory and chronic nature of constipation highlights the importance of considering a range of pathophysiological mechanisms, including the potential role of the gut microbiome. In this review, we provide an overview of preclinical and clinical studies that focus on the potential mechanisms through which the gut microbiome might contribute to the clinical presentation of functional constipation in pediatrics.
功能性便秘是儿童期的常见病症，对患者的生活质量和医疗资源有重大影响。功能性便秘的特征是排便次数减少和/或大便干结，这给儿童及其照顾者带来极大困扰。虽然“功能性”一词可能意味着不存在器质性病因，重点在于行为方面，但40%的儿童在常规治疗后仍有症状，四分之一的儿童便秘会持续到成年。便秘的难治性和慢性突出了考虑一系列病理生理机制的重要性，包括肠道微生物群的潜在作用。在本综述中，我们概述了临床前和临床研究，这些研究聚焦于肠道微生物群可能导致小儿功能性便秘临床表现的潜在机制。
