Department of Pediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.
Adv Clin Exp Med. 2021 Apr;30(4):471-480. doi: 10.17219/acem/131215.
Constipation is a widespread problem in pediatric practice, affecting almost 30% of pediatric population. As much as 90-95% of constipation cases have a functional basis, and although the pathogenesis of functional constipation remains unclear, its etiology is considered to be multifactorial. Its growing prevalence has been attributed to the occurrence of disorders in the homeostasis of gastrointestinal microbiota. In humans, the best known microbiome is that of the intestines, which has been the subject of a number of studies based on recognition of the 16S rRNA gene sequence. Microbiota are believed to influence the pathogenesis of functional constipation by affecting peristalsis, relationship with diet, and physical activity. The paper evaluates the role of intestinal microbiota in functional constipation and describes its contribution to the onset of disease. Determining the importance of the microbiome in the pathogenesis of functional constipation creates hope for the development of new prevention and treatment methods.
便秘是儿科实践中普遍存在的问题，几乎影响了 30%的儿科人群。多达 90-95%的便秘病例具有功能性基础，尽管功能性便秘的发病机制尚不清楚，但病因被认为是多因素的。其患病率的上升归因于胃肠道微生物组内稳态紊乱的发生。在人类中，最著名的微生物组是肠道微生物组，已经有许多基于识别 16S rRNA 基因序列的研究。微生物组被认为通过影响蠕动、与饮食和体力活动的关系来影响功能性便秘的发病机制。本文评估了肠道微生物群在功能性便秘中的作用，并描述了其对疾病发生的贡献。确定微生物组在功能性便秘发病机制中的重要性为开发新的预防和治疗方法带来了希望。
