钙向线粒体的转移：在意外情况下生命的一丝火花。
Ca transfer to mitochondria: a spark of life in unexpected conditions.
作者信息
Silva-Pavez Eduardo, Ahumada-Castro Ulises, Lovy Alenka, Cárdenas Julio Cesar
机构信息
Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.
Department of Neuroscience, Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
出版信息
Mol Cell Oncol. 2020 Dec 15;8(1):1839341. doi: 10.1080/23723556.2020.1839341. eCollection 2021.
Abstract
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor mitochondria could become a feasible therapeutic target to treat tumors that depend on reductive carboxylation.
摘要
肌醇1,4,5-三磷酸受体（InsP3R）介导的钙（Ca）向线粒体的转运对于维持正常细胞和癌细胞中的线粒体呼吸及生物能量学很重要，尽管癌细胞的氧化磷酸化（OXPHOS）存在缺陷。在此，我们讨论肿瘤线粒体如何能够成为治疗依赖还原羧化作用的肿瘤的一个可行治疗靶点。
相似文献
1
Ca transfer to mitochondria: a spark of life in unexpected conditions.钙向线粒体的转移：在意外情况下生命的一丝火花。
Mol Cell Oncol. 2020 Dec 15;8(1):1839341. doi: 10.1080/23723556.2020.1839341. eCollection 2021.
2
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca transfer for survival.功能失调的氧化磷酸化癌细胞需要内质网到线粒体的 Ca 转移来维持生存。
Sci Signal. 2020 Jul 14;13(640):eaay1212. doi: 10.1126/scisignal.aay1212.
3
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.组成型 IP3 受体将 Ca2+ 转移至线粒体对细胞生物能量学的基本调节作用。
Cell. 2010 Jul 23;142(2):270-83. doi: 10.1016/j.cell.2010.06.007.
4
Mitochondrial Ca(2+) signals in autophagy.自噬中的线粒体 Ca(2+)信号。
Cell Calcium. 2012 Jul;52(1):44-51. doi: 10.1016/j.ceca.2012.03.001. Epub 2012 Mar 28.
5
InsP3R, the calcium whisperer: Maintaining mitochondrial function in cancer.肌醇三磷酸受体，钙信号传递者：维持癌症中的线粒体功能
Mol Cell Oncol. 2016 May 11;3(4):e1185563. doi: 10.1080/23723556.2016.1185563. eCollection 2016 Jul.
6
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply.细胞质钙而非线粒体钙对于调节线粒体丙酮酸供应是必需的。
J Biol Chem. 2020 Apr 3;295(14):4383-4397. doi: 10.1074/jbc.RA119.011902. Epub 2020 Feb 24.
7
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells.Xestospongin B 通过抑制 InsP3R 减少 T 细胞急性淋巴细胞白血病细胞的线粒体呼吸并诱导选择性细胞死亡。
Int J Mol Sci. 2021 Jan 11;22(2):651. doi: 10.3390/ijms22020651.
8
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca Transfer.TOM70 通过促进 IP3R3 介导线粒体钙转移来维持细胞生物能量。
Curr Biol. 2018 Feb 5;28(3):369-382.e6. doi: 10.1016/j.cub.2017.12.047. Epub 2018 Jan 27.
9
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca communication: a dead end in cancer cells.被中断的内质网-线粒体钙通讯诱导的 MTOR 非依赖性自噬：癌细胞的死胡同。
Autophagy. 2019 Feb;15(2):358-361. doi: 10.1080/15548627.2018.1537769. Epub 2018 Oct 29.
10
Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand.纳米级别的细胞外钙离子按需调节谷氨酸依赖型氧化磷酸化。
PLoS One. 2009 Dec 9;4(12):e8181. doi: 10.1371/journal.pone.0008181.
引用本文的文献
1
ER-mitochondria contact sites; a multifaceted factory for Ca signaling and lipid transport.内质网-线粒体接触位点：一个用于钙信号传导和脂质转运的多面工厂。
Front Cell Dev Biol. 2022 Aug 16;10:988014. doi: 10.3389/fcell.2022.988014. eCollection 2022.
2
In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca Fluxes.在正确的时间处于正确的位置：IP3R介导的细胞器间钙通量对细胞代谢的调节
Front Cell Dev Biol. 2021 Mar 2;9:629522. doi: 10.3389/fcell.2021.629522. eCollection 2021.
本文引用的文献
1
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca transfer for survival.功能失调的氧化磷酸化癌细胞需要内质网到线粒体的 Ca 转移来维持生存。
Sci Signal. 2020 Jul 14;13(640):eaay1212. doi: 10.1126/scisignal.aay1212.
2
Mitochondria and Cancer.线粒体与癌症
Cell. 2016 Jul 28;166(3):555-566. doi: 10.1016/j.cell.2016.07.002.
3
Mitochondrial metabolic remodeling in response to genetic and environmental perturbations.线粒体代谢重塑对遗传和环境扰动的响应。
Wiley Interdiscip Rev Syst Biol Med. 2016 Jul;8(4):272-85. doi: 10.1002/wsbm.1334. Epub 2016 May 19.
4
Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.通过抑制钙离子从内质网向线粒体的转运实现癌细胞的选择性脆弱性
Cell Rep. 2016 Mar 15;14(10):2313-24. doi: 10.1016/j.celrep.2016.02.030. Epub 2016 Mar 3.
5
Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.线粒体呼吸在炎症性T细胞反应过程中控制溶酶体功能。
Cell Metab. 2015 Sep 1;22(3):485-98. doi: 10.1016/j.cmet.2015.07.020. Epub 2015 Aug 20.
6
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.α-酮戊二酸的氧化对于线粒体缺陷癌细胞中的还原性羧化作用是必需的。
Cell Rep. 2014 Jun 12;7(5):1679-1690. doi: 10.1016/j.celrep.2014.04.037. Epub 2014 May 22.
7
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
8
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.组成型 IP3 受体将 Ca2+ 转移至线粒体对细胞生物能量学的基本调节作用。
Cell. 2010 Jul 23;142(2):270-83. doi: 10.1016/j.cell.2010.06.007.
9
On the origin of cancer cells.论癌细胞的起源。
Science. 1956 Feb 24;123(3191):309-14. doi: 10.1126/science.123.3191.309.
10
Decoding of cytosolic calcium oscillations in the mitochondria.线粒体中胞质钙振荡的解码
Cell. 1995 Aug 11;82(3):415-24. doi: 10.1016/0092-8674(95)90430-1.
Zotero 插件