Valente Liz J, Attardi Laura D
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Mol Cell Oncol. 2021 Jan 11;8(1):1852066. doi: 10.1080/23723556.2020.1852066. eCollection 2021.
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the (tumor protein p53) gene is so prevalent in human cancers.
我们最近表明，在一种转化抑制模型中，p53肿瘤抑制因子同时调控众多细胞过程。这些发现表明，p53介导的肿瘤抑制依赖于在特定背景下对多种细胞功能的协同调节，这有助于解释为什么（肿瘤蛋白p53）基因的缺失在人类癌症中如此普遍。
