P53在肿瘤抑制过程中协调细胞过程的复杂交响曲。
P53 orchestrates a complex symphony of cellular processes during oncosuppression.
作者信息
Valente Liz J, Attardi Laura D
机构信息
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Mol Cell Oncol. 2021 Jan 11;8(1):1852066. doi: 10.1080/23723556.2020.1852066. eCollection 2021.
Abstract
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the (tumor protein p53) gene is so prevalent in human cancers.
摘要
我们最近表明，在一种转化抑制模型中，p53肿瘤抑制因子同时调控众多细胞过程。这些发现表明，p53介导的肿瘤抑制依赖于在特定背景下对多种细胞功能的协同调节，这有助于解释为什么（肿瘤蛋白p53）基因的缺失在人类癌症中如此普遍。
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本文引用的文献
1
p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.p53 缺陷在生理氧中触发多种细胞过程的失调。
J Cell Biol. 2020 Nov 2;219(11). doi: 10.1083/jcb.201908212.
2
DNA repair processes are critical mediators of p53-dependent tumor suppression.DNA 修复过程是 p53 依赖性肿瘤抑制的关键介质。
Nat Med. 2018 Jul;24(7):947-953. doi: 10.1038/s41591-018-0043-5. Epub 2018 Jun 11.
3
Deciphering p53 signaling in tumor suppression.解析肿瘤抑制中的 p53 信号通路。
Curr Opin Cell Biol. 2018 Apr;51:65-72. doi: 10.1016/j.ceb.2017.11.005. Epub 2017 Nov 28.
4
Deconstructing networks of p53-mediated tumor suppression in vivo.体内 p53 介导的肿瘤抑制网络的解构。
Cell Death Differ. 2018 Jan;25(1):93-103. doi: 10.1038/cdd.2017.171. Epub 2017 Nov 3.
5
Modeling Physiological Events in 2D vs. 3D Cell Culture.二维与三维细胞培养中生理事件的建模。
Physiology (Bethesda). 2017 Jul;32(4):266-277. doi: 10.1152/physiol.00036.2016.
6
Ferroptosis as a p53-mediated activity during tumour suppression.铁死亡作为肿瘤抑制过程中由p53介导的一种活动。
Nature. 2015 Apr 2;520(7545):57-62. doi: 10.1038/nature14344. Epub 2015 Mar 18.
7
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.为什么人体组织的部分氧分压是一个关键参数？小分子和缺氧。
J Cell Mol Med. 2011 Jun;15(6):1239-53. doi: 10.1111/j.1582-4934.2011.01258.x.
8
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts.氧气敏感性严重限制了小鼠成纤维细胞的复制寿命。
Nat Cell Biol. 2003 Aug;5(8):741-7. doi: 10.1038/ncb1024.
9
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10
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