Anand Naveen, Sharma Akhilesh, Shah Jimil, Kochhar Rakesh, Singh Shubh Mohan
Department of Psychiatry Postgraduate Institute of Medical Education and Research Chandigarh India.
Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.
JGH Open. 2021 Jan 12;5(2):301-306. doi: 10.1002/jgh3.12490. eCollection 2021 Feb.
Caustic ingestion is associated with long-term sequelae in the form of esophageal and/or gastric cicatrization requiring endoscopic or surgical intervention. Quality of life (QoL) and disability in patients with caustic-induced sequelae is less explored.
In this prospective study, we included consecutive patients with symptomatic caustic-induced esophageal stricture undergoing endoscopic dilatation. QoL was measured using the World Health Organization Quality of Life questionnaire (WHOQoL-BREF). Disability was measured using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). Subjective dysphagia score was calculated by Likert scale.
A total of 42 patients were included in the study; 25 (59.5%) patients were male. Patients had poor WHOQoL-BREF and WHODAS scores compared to normality data in all domains of the scores among both the genders. A majority (66.7%) of patients had a current psychiatric diagnosis, with the most common being mood disorder (50%) followed by suicidality (45.2%). Males had a higher prevalence of a previous psychiatric diagnosis compared to females, while females had a higher prevalence of suicidality. Dysphagia score had strong correlation with the WHOQoL ( = -0.66; < 0.01) and WHODAS ( = 0.71; < 0.01).
Patients with esophageal stricture due to caustic ingestion on long-term endoscopic dilatation have poor QoL, high prevalence of psychological morbidity, and disability.
腐蚀性物质摄入会导致食管和/或胃瘢痕形成的长期后遗症，需要进行内镜或手术干预。对于腐蚀性物质所致后遗症患者的生活质量（QoL）和残疾情况，人们了解较少。
在这项前瞻性研究中，我们纳入了连续的因腐蚀性物质导致食管狭窄且有症状并接受内镜扩张治疗的患者。使用世界卫生组织生活质量问卷（WHOQoL-BREF）来测量生活质量。使用世界卫生组织残疾评估量表2.0（WHODAS 2.0）来测量残疾情况。通过李克特量表计算主观吞咽困难评分。
该研究共纳入42例患者；25例（59.5%）为男性。与正常数据相比，男女患者在所有评分领域的WHOQoL-BREF和WHODAS评分均较差。大多数（66.7%）患者目前有精神科诊断，最常见的是情绪障碍（50%），其次是自杀倾向（45.2%）。男性既往精神科诊断的患病率高于女性，而女性自杀倾向的患病率更高。吞咽困难评分与WHOQoL（r = -0.66；P < 0.01）和WHODAS（r = 0.71；P < 0.01）有很强的相关性。
因腐蚀性物质摄入导致食管狭窄并长期接受内镜扩张治疗的患者生活质量较差，心理疾病患病率高，且存在残疾情况。
