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双胎妊娠中母体和脐血管中的血浆脂质及高密度脂蛋白胆固醇

Plasma lipids and high density lipoprotein cholesterol in maternal and umbilical vessels in twin pregnancies.

作者信息

Ramón y Cajal J, Pocoví M, Romero M A, Jimenez D, Martinez H, Grande F

机构信息

Department of Biochemistry, Faculty Sciences, University of Zaragoza, Spain.

出版信息

Artery. 1988;15(2):109-17.

PMID:3355377
Abstract

Total cholesterol (TC), triglycerides (TG), phospholipids (PL), Unesterified cholesterol (UC) and high-density lipoprotein cholesterol (HDL) were measured in 30 plasmas from twin pregnant women and their newborns, and 60 maternal single infant pairs. Blood samples were obtained simultaneously from maternal vein, umbilical artery and umbilical vein at the moment of partum. TG from twin pregnant mothers was much higher and HDL-C lower than that from single pregnant maternal plasma TC, TG and PL in umbilical cord vessels showed no differences between twin and single newborns. There was a weak, but statistically significant, positive correlation between maternal and fetal levels of PL in both groups. A high difference between TC, TG and PL in umbilical venous and umbilical arterial plasma was found These data suggest that some fetal lipid moieties derived from maternal plasma. But data about fetal body composition indicate that contribution of maternal lipids to the fetus is of small quantitative importance.

摘要

对30对双胞胎孕妇及其新生儿以及60对单胎孕妇及其新生儿的血浆进行了总胆固醇(TC)、甘油三酯(TG)、磷脂(PL)、游离胆固醇(UC)和高密度脂蛋白胆固醇(HDL)的检测。在分娩时同时从孕妇静脉、脐动脉和脐静脉采集血样。双胞胎孕妇母亲的TG水平明显高于单胎孕妇,而HDL-C水平则低于单胎孕妇。脐带血管中的血浆TC、TG和PL在双胞胎和单胎新生儿之间没有差异。两组中母体和胎儿的PL水平之间存在微弱但具有统计学意义的正相关。脐静脉和脐动脉血浆中的TC、TG和PL存在很大差异。这些数据表明,一些胎儿脂质部分源自母体血浆。但有关胎儿身体成分的数据表明,母体脂质对胎儿的贡献在数量上并不重要。

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Lipid metabolism in pregnancy and its consequences in the fetus and newborn.孕期脂质代谢及其对胎儿和新生儿的影响。
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