洋葱提取物、外用类固醇和凡士林润肤剂对上睑成形术瘢痕外观的效果比较。
Comparison of the Effectiveness of Onion Extract, Topical Steroid, and Petrolatum Emollient in Cosmetic Appearance of Upper Blepharoplasty Scar.
作者信息
Owji Naser, Khalili Mohammad Reza, Khademi Behzad, Shirvani Mohammad, Sadati Maryam Sadat
机构信息
Department of Ophthalmology, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
J Curr Ophthalmol. 2020 Dec 12;32(4):408-413. doi: 10.4103/JOCO.JOCO_39_20. eCollection 2020 Oct-Dec.
PURPOSE
To compare the effectiveness of onion extract, topical steroid, and petrolatum emollient in the prevention of scars in cases who underwent bilateral upper eyelid blepharoplasty.
METHODS
A prospective, interventional, comparative, double-blinded case series was designed on cases who underwent upper lid blepharoplasty. After suture removal (1 week following the surgery), the eyelids of participants were randomly allocated into the three groups: The first group used onion extract on the right eyelids ( = 18), and the second group used topical steroid on the right eyelids ( = 19). In the third group, the control group, petrolatum emollient was used on the left eyelids ( = 37) of the first and second group's cases. They used drugs for 2 months and were evaluated by the Manchester Scar Scale (MSS) objectively by two graders who were blinded to the type of medication. MSS evaluates five different characteristics of the scar in addition to the Visual Analog Scale (VAS). These characteristics include color, distortion, contour, texture, and transparency. VAS scores the overall scar appearance which ranged among 0-10. The sum of the scores for the five different parameters, and VAS was calculated, analyzed, and compared among the groups.
RESULTS
A total of 37 cases (74 eyelids) who underwent bilateral upper blepharoplasty were included. The mean ± standard deviation (SD) of age was 51.94 ± 9.26 years, 49.40 ± 9.37 years, and 47.00 ± 9.06 years in the onion extract, topical steroid, and petrolatum emollient groups, respectively ( = 0.275). There were no statistically significant differences in the mean ± SD of the sum of the MSS scores among the three groups ( = 0.924) or between the onion extract and topical steroid groups ( = 0.951). Furthermore, the color, distortion, contour, texture, transparency, and VAS scores were not statistically significantly different among the three groups or between the onion extract and topical steroid groups (P > 0.05).
CONCLUSION
There were no significant differences among these three groups of drugs regarding the appearance of the upper blepharoplasty scar.
目的
比较洋葱提取物、外用类固醇和凡士林润肤剂在双侧上睑成形术患者中预防瘢痕形成的效果。
方法
对接受上睑成形术的患者设计了一项前瞻性、干预性、对比性、双盲病例系列研究。拆线后（手术后1周），将参与者的眼睑随机分为三组：第一组在右眼睑使用洋葱提取物（n = 18），第二组在右眼睑使用外用类固醇（n = 19）。在第三组即对照组中，第一组和第二组病例的左眼睑（n = 37）使用凡士林润肤剂。他们使用药物2个月，并由两名对药物类型不知情的分级者通过曼彻斯特瘢痕量表（MSS）进行客观评估。MSS除视觉模拟量表（VAS）外，还评估瘢痕的五个不同特征。这些特征包括颜色、变形、轮廓、质地和透明度。VAS对瘢痕的整体外观进行评分，范围为0至10分。计算、分析并比较三组中五个不同参数的得分总和以及VAS。
结果
总共纳入了37例（74只眼睑）接受双侧上睑成形术的患者。洋葱提取物组、外用类固醇组和凡士林润肤剂组的年龄均值±标准差（SD）分别为51.94±9.26岁、49.40±9.37岁和47.00±9.06岁（P = 0.275）。三组间MSS评分总和的均值±SD无统计学显著差异（P = 0.924），洋葱提取物组和外用类固醇组之间也无显著差异（P = 0.951）。此外，三组之间以及洋葱提取物组和外用类固醇组之间的颜色、变形、轮廓、质地、透明度和VAS评分均无统计学显著差异（P>0.05）。
结论
这三组药物在上睑成形术瘢痕外观方面无显著差异。
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