帕金森病中的掌颏反射。与正常受试者的比较及临床相关性。

The palmomental reflex in Parkinson's disease. Comparisons with normal subjects and clinical relevance.

作者信息

Maertens de Noordhout A, Delwaide P J

机构信息

Section of Neurology and Clinical Neurophysiology, University of Liège, Belgium.

出版信息

Arch Neurol. 1988 Apr;45(4):425-7. doi: 10.1001/archneur.1988.00520280075018.

DOI:10.1001/archneur.1988.00520280075018

PMID:3355398

Abstract

We tested 356 normal subjects and 109 parkinsonian patients for the palmomental reflex. The total incidence of the reflex was 16.3% in normal subjects, increasing with age. In parkinsonian patients, the overall incidence of the reflex was 71.5%, without clear effect of age. A positive correlation was found between degree of akinesia and incidence as well as intensity of the reflex. In the dyskinetic patients, the reflex was seldom elicited, and, if so, it was small. Modifications of the characteristics of the response could be disclosed in parallel with variations of the patient's clinical status. These findings suggest that the presence of a palmomental reflex in parkinsonian patients could indirectly reflect the decrease of dopaminergic activity in the nigrostriatal pathways.

摘要

我们对356名正常受试者和109名帕金森病患者进行了掌颏反射测试。该反射在正常受试者中的总发生率为16.3%，随年龄增长而增加。在帕金森病患者中，该反射的总体发生率为71.5%，年龄对其无明显影响。发现运动不能程度与反射的发生率及强度之间呈正相关。在运动障碍患者中，很少引出该反射，即便引出，其反应也很微弱。反应特征的改变可与患者临床状态的变化同时显现。这些发现提示，帕金森病患者中掌颏反射的存在可能间接反映黑质纹状体通路中多巴胺能活性的降低。