Abdullah Ansifa S, Sundaram Shanthosh P, Barooah Rituparna
Department of Physiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.
Department of Community Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.
Indian J Endocrinol Metab. 2025 Jul-Aug;29(4):458-464. doi: 10.4103/ijem.ijem_469_24. Epub 2025 Aug 26.
The relationship between Vitamin D (VitD) levels and cognitive function in young adults remains unclear, with conflicting results in existing literature. This study aimed to assess the prevalence of VitD deficiency and mild cognitive impairment (MCI) and to explore the correlation between serum VitD levels and cognitive functions in young indigenous adults in Meghalaya.
A hospital-based cross-sectional study was conducted in a tertiary care centre in Shillong, Meghalaya, involving 137 healthy young individuals associated with the centre. Serum VitD levels were measured and categorised according to the classifications of the Food and Nutrition Board, National Academies of Sciences, Engineering, and Medicine, and the Endocrine Society. Cognitive functions were assessed using the Montreal Cognitive Assessment scale.
Based on the Endocrine Society Classification, 85.4% (95% CI: 78.5%-90.3%) of participants were found to be VitD-deficient, and 51.1% (95% CI: 42.4%-59.7%) had MCI. A statistically significant positive correlation was observed between serum VitD levels and cognitive functions (r = 0.096; = 0.025). Adequate sun exposure was independently associated with higher serum VitD levels, and females were found to have better cognition.
The study revealed a high prevalence of VitD deficiency and MCI in the young indigenous population with an identified positive association between the two conditions. However, the findings highlight the need for large-scale, multi-centric, longitudinal studies with follow-up assessments to further understand these relationships.
维生素D（VitD）水平与年轻人认知功能之间的关系仍不明确，现有文献结果相互矛盾。本研究旨在评估维生素D缺乏症和轻度认知障碍（MCI）的患病率，并探讨梅加拉亚邦年轻原住民血清维生素D水平与认知功能之间的相关性。
在梅加拉亚邦西隆的一家三级医疗中心进行了一项基于医院的横断面研究，涉及137名与该中心相关的健康年轻人。根据美国国家科学院、工程院和医学院食品与营养委员会以及内分泌学会的分类标准，测量血清维生素D水平并进行分类。使用蒙特利尔认知评估量表评估认知功能。
根据内分泌学会的分类标准，发现85.4%（95%CI：78.5%-90.3%）的参与者维生素D缺乏，51.1%（95%CI：42.4%-59.7%）患有MCI。血清维生素D水平与认知功能之间存在统计学上显著的正相关（r = 0.096；P = 0.025）。充足的阳光照射与较高的血清维生素D水平独立相关，并且发现女性认知功能更好。
该研究揭示了年轻原住民中维生素D缺乏症和MCI的高患病率，且确定了这两种情况之间存在正相关。然而，研究结果强调需要进行大规模、多中心的纵向研究以及随访评估，以进一步了解这些关系。
