Meyer Ralph G, Meyer-Ficca Mirella L
Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84332, USA.
Utah Experimental Station, Utah State University, Logan, UT 84332, USA.
Adv Geriatr Med Res. 2021;3(1). doi: 10.20900/agmr20210005. Epub 2021 Jan 12.
Similar to female reproductive health, male reproductive health declines with increasing age, albeit in a more gradual way. In the US, the average age of first-time fathers has been steadily increasing since 1980. This is concerning because increasing paternal age is positively correlated with reduced sperm chromatin quality and higher numbers of DNA strand breaks (DNA sb), which negatively affects pregnancy outcome and child development. While underlying reasons are not well understood, one of the well-known hallmarks of aging is a significant decline of body nicotinamide adenine dinucleotide (NAD) levels. We propose that low body-wide NAD levels provide a plausible explanation for metabolic alterations that are associated with declining hormonal production and testicular volume, as well as reduced sperm quality in aging men.
与女性生殖健康类似，男性生殖健康也会随着年龄增长而下降，尽管其过程更为缓慢。在美国，自1980年以来，初为人父者的平均年龄一直在稳步上升。这令人担忧，因为父亲年龄的增加与精子染色质质量下降以及更多的DNA链断裂呈正相关，这会对妊娠结局和儿童发育产生负面影响。虽然其根本原因尚不完全清楚，但衰老的一个众所周知的特征是体内烟酰胺腺嘌呤二核苷酸（NAD）水平显著下降。我们认为，全身低NAD水平为与激素分泌减少、睾丸体积减小以及老年男性精子质量下降相关的代谢改变提供了一个合理的解释。
