Rocky Mountain Regional Veterans Hospital, Aurora, CO, USA.
Department of Surgery/Urology, University of Colorado Anschutz School of Medicine, Aurora, CO, 80045, USA.
Curr Urol Rep. 2021 Feb 8;22(4):21. doi: 10.1007/s11934-020-01031-9.
Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) is a disease complex with enormous societal burden and yet the pathogenesis of LUTS/BPH is poorly understood. We set out to review the literature on the relationship between depression, marijuana usage, and erectile dysfunction (ED) to LUTS/BPH.
LUTS/BPH has independent associations with depression as well as with ED. In each case, the causality and mechanistic relationship is unknown. The impact of marijuana, as it increasingly pervades the general population, on the disease complex of LUTS/BPH is not well studied but recent results support short-term benefit and long-term caution. Depression, a form of central nervous dysfunction, and ED, which is likely mediated via endothelial dysfunction, are independently associated with LUTS/BPH. The presence of cannabinoid receptors in urologic organs, coupled with recent population studies, supports a modulatory effect of marijuana on voiding although an enormous knowledge gap remains.
良性前列腺增生（BPH）和下尿路症状（LUTS）是一种具有巨大社会负担的疾病，但其发病机制尚不清楚。我们旨在综述有关抑郁、大麻使用与勃起功能障碍（ED）与 LUTS/BPH 之间关系的文献。
LUTS/BPH 与抑郁以及 ED 均有独立的关联。在每种情况下，因果关系和机制关系均不明确。大麻的影响，随着其在普通人群中的日益普及，对 LUTS/BPH 这一疾病的影响尚未得到很好的研究，但最近的结果支持短期获益和长期谨慎。抑郁是一种中枢神经系统功能障碍，而 ED 可能是通过内皮功能障碍介导的，它们与 LUTS/BPH 均有独立的关联。在泌尿科器官中存在大麻素受体，加上最近的人群研究，支持大麻对排尿有调节作用，尽管仍存在巨大的知识空白。
