血清促红细胞生成素、铁调素和结合珠蛋白水平与 COVID-19 患者疾病严重程度及其他生化值的关系。
The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19.
机构信息
Department of Clinical Biochemistry, Sisli Hamidiye Etfal Research and Training Hospital, University of Health Sciences, Sisli, Turkey.
Department of Intensive Care Unit, Sisli Hamidiye Etfal Research and Training Hospital, University of Health Sciences, Sisli, Turkey.
出版信息
Int J Lab Hematol. 2021 Jul;43 Suppl 1(Suppl 1):142-151. doi: 10.1111/ijlh.13479. Epub 2021 Feb 7.
INTRODUCTION
Studies have shown that iron metabolism is affected by coronavirus disease 19 (COVID-19), which has spread worldwide and has become a global health problem. Our study aimed to evaluate the relationship between COVID-19 and serum erythropoietin (EPO), hepcidin, and haptoglobin (Hpt) levels with disease severity, and other biochemical values.
METHODS
Fifty nine COVID-19 patients hospitalized in the intensive care unit (ICU) and wards in our hospital between March and June 2020 and 19 healthy volunteers were included in the study. Participants were divided into mild, severe, and critical disease severity groups. Group mean values were analyzed with SPSS according to disease severity, mortality, and intubation status.
RESULTS
Hemoglobin (Hb) levels were significantly lower in the critical patient group (P < .0001) and deceased group (P < .0001). The red blood cell distribution width-coefficient of variation (RDW-CV) and ferritin values were significantly higher in the intubated (P = .001, P = .005) and deceased (P = .014, P = .003) groups. Ferritin values were positively correlated with disease severity (P < .0001). Serum iron levels were lower in the patient group compared with the reference range. (P < .0001). It was found that the transferrin saturation (TfSat) was lower in the patient group compared with the control group (P < .0001). It was found that the mean EPO of the deceased was lower than the control group and the survived patient group (P = .035). Hepcidin levels were found to be significantly lower in the patient group (P < .0001). Hpt values were found to be significantly lower in the intubated group (P = .004) and the deceased group (P = .042).
CONCLUSION
In our study, while serum iron and hepcidin levels decreased in patients diagnosed with COVID-19, we found that EPO and Hpt levels were significantly lower in critical and deceased patient groups. Our study is the first study examining EPO and Hpt levels in patients diagnosed with COVID-19.
简介
研究表明，铁代谢受 2019 年冠状病毒病（COVID-19）的影响，COVID-19 已在全球范围内传播，成为全球健康问题。本研究旨在评估 COVID-19 与血清促红细胞生成素（EPO）、铁调素和结合珠蛋白（Hpt）水平与疾病严重程度以及其他生化值之间的关系。
方法
2020 年 3 月至 6 月期间，我们将 59 名在我院重症监护病房（ICU）和病房住院的 COVID-19 患者和 19 名健康志愿者纳入研究。根据疾病严重程度、死亡率和插管状态，将参与者分为轻症、重症和危重症组。采用 SPSS 对组间均值进行分析。
结果
危重症组（P<0.0001）和死亡组（P<0.0001）的血红蛋白（Hb）水平显著降低。插管组（P=0.001，P=0.005）和死亡组（P=0.014，P=0.003）的红细胞分布宽度变异系数（RDW-CV）和铁蛋白值显著升高。铁蛋白值与疾病严重程度呈正相关（P<0.0001）。与参考范围相比，患者组的血清铁水平较低（P<0.0001）。与对照组相比，患者组的转铁蛋白饱和度（TfSat）较低（P<0.0001）。发现死亡组的平均 EPO 低于对照组和存活患者组（P=0.035）。患者组的铁调素水平显著降低（P<0.0001）。发现插管组（P=0.004）和死亡组（P=0.042）的 Hpt 值显著降低。
结论
在本研究中，我们发现 COVID-19 患者的血清铁和铁调素水平降低，而 EPO 和 Hpt 水平在危重症和死亡患者组中显著降低。我们的研究是首次检查 COVID-19 患者的 EPO 和 Hpt 水平。
Zotero 插件