代谢综合征患者的促红细胞生成素、铁蛋白、结合珠蛋白、血红蛋白和转铁蛋白受体：一项病例对照研究。

Erythropoietin, ferritin, haptoglobin, hemoglobin and transferrin receptor in metabolic syndrome: a case control study.

机构信息

Department of Internal Medicine, Tampere University Hospital, Teiskontie, Tampere, Finland.

出版信息

Cardiovasc Diabetol. 2012 Sep 27;11:116. doi: 10.1186/1475-2840-11-116.

DOI:10.1186/1475-2840-11-116

PMID:23016887

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3471017/

Abstract

BACKGROUND

Increased ferritin concentrations are associated with metabolic syndrome (MetS). The association between ferritin as well as hemoglobin level and individual MetS components is unclear. Erythropoietin levels in subjects with MetS have not been determined previously. The aim of this study was to compare serum erythropoietin, ferritin, haptoglobin, hemoglobin, and transferrin receptor (sTFR) levels between subjects with and without MetS and subjects with individual MetS components.

METHODS

A population based cross-sectional study of 766 Caucasian, middle-aged subjects (341 men and 425 women) from five age groups born in Pieksämäki, Finland who were invited to a health check-up in 2004 with no exclusion criteria. Laboratory analyzes of blood samples collected in 2004 were done during year 2010. MetS was defined by National Cholesterol Education Program criteria.

RESULTS

159 (53%) men and 170 (40%) women of study population met MetS criteria. Hemoglobin and ferritin levels as well as erythropoietin and haptoglobin levels were higher in subjects with MetS (p < 0.001, p = 0.018). sTFR level did not differ significantly between subjects with or without MetS. Hemoglobin level was significantly higher in subjects with any of the MetS components (p < 0.001, p = 0.002). Ferritin level was significantly higher in subjects with abdominal obesity or high TG or elevated glucose or low high density cholesterol component (p < 0.001, p = 0.002, p = 0.02). Erythropoietin level was significantly higher in subjects with abdominal obesity component (p = 0.015) but did not differ significantly between subjects with or without other MetS components. Haptoglobin level was significantly higher in subjects with blood pressure or elevated glucose component o MetS (p = 0.028, p = 0.025).

CONCLUSION

Subjects with MetS have elevated hemoglobin, ferritin, erythropoietin and haptoglobin concentrations. Higher hemoglobin levels are related to all components of MetS. Higher ferritin levels associate with TG, abdominal obesity, elevated glucose or low high density cholesterol. Haptoglobin levels associate with blood pressure or elevated glucose. However, erythropoietin levels are related only with abdominal obesity. Higher serum erythropoietin concentrations may suggest underlying adipose tissue hypoxemia in MetS.

摘要

背景

铁蛋白浓度升高与代谢综合征（MetS）有关。铁蛋白和血红蛋白水平与单个 MetS 成分之间的关系尚不清楚。以前没有确定 MetS 患者的促红细胞生成素水平。本研究的目的是比较 MetS 患者与非 MetS 患者以及具有单个 MetS 成分的患者之间的血清促红细胞生成素、铁蛋白、触珠蛋白、血红蛋白和转铁蛋白受体（sTFR）水平。

方法

这是一项基于人群的横断面研究，共纳入了 766 名来自芬兰皮克萨米基的白种中年人（341 名男性和 425 名女性），他们来自五个年龄组，于 2004 年参加了健康检查，没有排除标准。2004 年采集的血液样本的实验室分析于 2010 年进行。MetS 按照国家胆固醇教育计划标准定义。

结果

研究人群中有 159 名男性（53%）和 170 名女性（40%）符合 MetS 标准。铁蛋白和血红蛋白水平以及促红细胞生成素和触珠蛋白水平在 MetS 患者中更高（p<0.001，p=0.018）。sTFR 水平在 MetS 患者与非 MetS 患者之间无显著差异。任何 MetS 成分患者的血红蛋白水平均显著升高（p<0.001，p=0.002）。铁蛋白水平在腹型肥胖或高甘油三酯或血糖升高或低高密度胆固醇成分患者中显著升高（p<0.001，p=0.002，p=0.02）。促红细胞生成素水平在腹型肥胖成分患者中显著升高（p=0.015），但在无其他 MetS 成分患者之间无显著差异。触珠蛋白水平在 MetS 患者的血压或血糖升高成分中显著升高（p=0.028，p=0.025）。

结论

MetS 患者的血红蛋白、铁蛋白、促红细胞生成素和触珠蛋白浓度升高。较高的血红蛋白水平与 MetS 的所有成分相关。较高的铁蛋白水平与甘油三酯、腹型肥胖、血糖升高或低高密度胆固醇相关。触珠蛋白水平与血压或血糖升高相关。然而，促红细胞生成素水平仅与腹型肥胖相关。较高的血清促红细胞生成素浓度可能表明 MetS 中潜在的脂肪组织缺氧。