Andretta Maria Eduarda, Frizzo Matias Nunes, Goettems-Fiorin Pauline Brendler, Heck Thiago Gomes, Sulzbacher Lucas Machado, Sulzbacher Maicon Machado, Ludwig Mirna Stela, Favero Gaia, Rezzani Rita, de Oliveira Vitor Antunes
Department of Biomedicine, Regional University of Northwestern Rio Grande do Sul State (UNIJUÍ), Rua do Comércio, 3000-University, Ijuí 98700-000, RS, Brazil.
Research Group in Physiology, Department of Life Sciences, Regional University of Northwestern Rio Grande do Sul State (UNIJUÍ), Rua do Comércio, 3000-University, Ijuí 98700-000, RS, Brazil.
Int J Mol Sci. 2025 Apr 27;26(9):4135. doi: 10.3390/ijms26094135.
Coronavirus disease 2019 (COVID-19) has posed unprecedented challenges to global public health, highlighting the importance of prognostic biomarkers in critically ill patients. The oxidative stress developed in COVID-19 is associated with impairment in various human organs and systems, and it is related to erythrocyte injury, leading to an elevation in red cell distribution width (RDW) and systemic inflammation. This study aims to assess the prognostic value of erythrogram indicators and C-reactive protein (CRP) levels in 91 intensive care unit-admitted COVID-19 patients, categorized into survivor patients (discharge group) and non-survivor patients (death group). The results were presented using descriptive statistics and the Mann-Whitney test. The most severe cases of respiratory failure in which the patients did not survive showed higher red cell distribution width (RDW) and lower values of red blood cell count, hemoglobin, and hematocrit. RDW may be an important indicator of mortality, as demonstrated by the receiver operating characteristic (ROC) curve analysis. Furthermore, this increase in RDW is correlated with elevated CRP levels, another important clinical outcome for these patients. In conclusion, elevated RDW and CRP levels at admission may be reliable predictors of unfavorable outcomes, emphasizing the utility of these indicators in clinical assessments of COVID-19 patients.
2019冠状病毒病（COVID-19）给全球公共卫生带来了前所未有的挑战，凸显了危重症患者预后生物标志物的重要性。COVID-19中产生的氧化应激与人体各器官和系统的损伤有关，并且与红细胞损伤相关，导致红细胞分布宽度（RDW）升高和全身炎症。本研究旨在评估91例入住重症监护病房的COVID-19患者的血常规指标和C反应蛋白（CRP）水平的预后价值，这些患者分为存活患者（出院组）和非存活患者（死亡组）。结果采用描述性统计和曼-惠特尼检验进行呈现。患者未存活的最严重呼吸衰竭病例显示出较高的红细胞分布宽度（RDW）以及较低的红细胞计数、血红蛋白和血细胞比容值。如受试者工作特征（ROC）曲线分析所示，RDW可能是死亡率的一个重要指标。此外，RDW的这种升高与CRP水平升高相关，CRP水平升高是这些患者的另一个重要临床结果。总之，入院时RDW和CRP水平升高可能是不良预后的可靠预测指标，强调了这些指标在COVID-19患者临床评估中的实用性。
