Department of Obstetrics and Gynecology, Chang'an Hospital, Xi'an, Shaanxi Province, P.R. China.
Department of Obstetrics and Gynecology, Xijing Hospital of the Air Force Military Medical University, Xi'an, Shaanxi Province, P.R. China.
J Perinat Med. 2020 Dec 18;49(4):480-484. doi: 10.1515/jpm-2020-0318. Print 2021 May 26.
Vitamin D plays an important role in the release of the placenta and implantation, and low levels are a risk factor for pre-eclampsia. Studies have also shown that symptomatic treatment of vitamin D3 deficiency can effectively reduce the risk of pre-eclampsia. In this study, vitamin D3 supplementation was performed on the risk of pre-eclampsia to observe its effect.
From January 2016 to December 2018, 450 women with maternal treatment and delivery in our hospital underwent an open-label randomized study. The pregnant women were divided into low-dose, medium-dose, and high-dose groups. Compare the incidence of pre-eclampsia and the dose effect of vitamin D levels.
In the maternal and perinatal periods of the 450 maternal women, the 25[OH] index of the three groups of pregnant women was significantly increased, while the high-dose increase index was more obvious. The relative risk reduction rate was significantly lower. Compared with the low-dose and middle-dose groups, the high-dose group had a significantly lower incidence of pre-eclampsia, while the IUGR index was lower, and other obstetric indicators were comparable.
Vitamin D supplementation can effectively reduce the incidence of pre-eclampsia, while reducing the IUGR index, which has important value and significance in its clinical application.
维生素 D 在胎盘释放和植入中起着重要作用，其水平低是子痫前期的一个危险因素。研究还表明，维生素 D3 缺乏的症状性治疗可以有效降低子痫前期的风险。本研究对维生素 D3 补充预防子痫前期的风险进行了观察，以观察其效果。
2016 年 1 月至 2018 年 12 月，我院收治的 450 例母婴治疗和分娩的孕妇进行了一项开放性随机研究。将孕妇分为低剂量组、中剂量组和高剂量组。比较子痫前期的发生率和维生素 D 水平的剂量效应。
在 450 例母婴期的孕妇中，三组孕妇的 25[OH] 指数均明显升高，而高剂量组的升高指数更为明显。相对危险降低率明显降低。与低剂量组和中剂量组相比，高剂量组子痫前期的发生率明显降低，而 IUGR 指数较低，其他产科指标相当。
维生素 D 补充可有效降低子痫前期的发生率，同时降低 IUGR 指数，在其临床应用中具有重要的价值和意义。
