Xu Lian-Hong, Zhang Ying, Wang Yong, Hu Die, Xu Jia-Hao
Department of Clinical Laboratory Examination, The Wujin Hospital Affiliated to Jiangsu University,Changzhou 213017, Jiangsu Province, China ,Department of Clinical Laboratory Examination, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, Jiangsu Province, China,E-mail:
Department of Clinical Laboratory Examination, The Wujin Hospital Affiliated to Jiangsu University,Changzhou 213017, Jiangsu Province, China ,Department of Clinical Laboratory Examination, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Feb;29(1):213-216. doi: 10.19746/j.cnki.issn.1009-2137.2021.01.034.
To detect serum hepcidin and erythroferrone levels in child-bearing women with iron deficiency anemia (IDA), and to investigate the association between them and iron status parameters.
The study consisted of 65 child-bearing women (35 with iron deficiency anemia and 30 age-matched healthy women). The levels of serum iron were detected by using automated chemistry analyzer, the contents of serum ferritin were detected by electrochemiluminescence immunoassay, and the levels of serum erythroferrone and hepcidin were detected by specific enzyme-linked immunosorbent assay (ELISA) kit. The quantitative variables between two groups were compared and analyzed by SPSS22.0 software. Spearman correlation was used to detect correlation between the parameters.
The levels of Hb, serum iron, ferritin and transferrin saturation were significantly decreased in IDA patients as compared with in control group (P<0.001). Serum hepcidin levels in IDA patients were significant lower than those in control group (P<0.001). Serum erythroferrone levels slightly increased in IDA group (P>0.05). In IDA patients, serum hepcidin concentrations were positively correlated with hemoglobin concentration, serum iron, serum ferritin and transferrin saturation (r=0.448, r=0.496, r=0.754, r=0.491). But, serum erythroferrone concentrations showed no correlation with hemoglobin concentration, serum iron, serum ferritin, transferrin saturation and hepcidin (P>0.05).
Serum hepcidin levels were significantly decreased in child-bearing women with IDA, but the serum erythroferrone levels were not obviously different between two groups, suggesting that serum erythroferrone may be not involved in the regulation of iron metabolism in child-bearing women with mild and moderate IDA.
检测缺铁性贫血（IDA）育龄妇女血清铁调素和红细胞铁调素水平，并探讨它们与铁状态参数之间的关系。
本研究纳入65名育龄妇女（35名缺铁性贫血患者和30名年龄匹配的健康妇女）。采用自动生化分析仪检测血清铁水平，用电化学发光免疫分析法检测血清铁蛋白含量，用特异性酶联免疫吸附测定（ELISA）试剂盒检测血清红细胞铁调素和铁调素水平。两组间的定量变量采用SPSS22.0软件进行比较和分析。采用Spearman相关性分析检测参数之间的相关性。
与对照组相比，IDA患者的血红蛋白、血清铁、铁蛋白和转铁蛋白饱和度水平显著降低（P<0.001）。IDA患者血清铁调素水平显著低于对照组（P<0.001）。IDA组血清红细胞铁调素水平略有升高（P>0.05）。在IDA患者中，血清铁调素浓度与血红蛋白浓度、血清铁、血清铁蛋白和转铁蛋白饱和度呈正相关（r=0.448，r=0.496，r=0.754，r=0.491）。但是，血清红细胞铁调素浓度与血红蛋白浓度、血清铁、血清铁蛋白、转铁蛋白饱和度和铁调素均无相关性（P>0.05）。
IDA育龄妇女血清铁调素水平显著降低，但两组血清红细胞铁调素水平无明显差异，提示血清红细胞铁调素可能不参与轻度和中度IDA育龄妇女铁代谢的调节。
