Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041 Shantou, Guangdong, China.
Clin Exp Med. 2011 Mar;11(1):33-42. doi: 10.1007/s10238-010-0102-9. Epub 2010 May 25.
Hepcidin is a key hormone governing mammalian iron homeostasis and may be directly or indirectly involved in the development of most iron deficiency/overload and inflammation-induced anemia. The objective of this study was to investigate the expression of hepcidin in anemia of chronic disease. To characterize serum hepcidin, iron and inflammatory indicators associated with anemia of chronic disease (ACD), we studied ACD, ACD concomitant iron-deficiency anemia (ACD/IDA), pure IDA and acute inflammation (AcI) patients and analyzed the associations between hepcidin levels and inflammation parameters in various types of anemia. Serum hepcidin levels in patient groups were statistically different, from high to low: ACD, AcI > ACD/IDA > the control > IDA. Serum ferritin levels were significantly increased in ACD and AcI patients but were decreased significantly in ACD/IDA and IDA. Elevated serum EPO concentrations were found in ACD, ACD/IDA and IDA patients but not in AcI patients and the controls. A positive correlation between hepcidin and IL-6 levels only existed in ACD/IDA, AcI and the control groups. A positive correlation between hepcidin and ferritin was marked in the control group, while a negative correlation between hepcidin and ferritin was noted in IDA. The significant negative correlation between hepcidin expression and reticulocyte count was marked in both ACD/IDA and IDA groups. All of these data demonstrated that hepcidin might play role in pathogenesis of ACD, ACD/IDA and IDA, and it could be a potential marker for detection and differentiation of these anemias.
铁调素是调节哺乳动物铁稳态的关键激素，可能直接或间接参与大多数缺铁/过载和炎症引起的贫血的发生。本研究旨在探讨慢性病贫血中铁调素的表达。为了描述与慢性病贫血（ACD）相关的铁和炎症指标的血清铁调素，我们研究了 ACD、ACD 合并缺铁性贫血（ACD/IDA）、单纯缺铁性贫血（IDA）和急性炎症（AcI）患者，并分析了各种类型贫血中铁调素水平与炎症参数之间的关系。患者组血清铁调素水平从高到低依次为：ACD、AcI > ACD/IDA > 对照组 > IDA。ACD 和 AcI 患者的血清铁蛋白水平显著升高，但 ACD/IDA 和 IDA 患者的血清铁蛋白水平显著降低。ACD、ACD/IDA 和 IDA 患者的血清 EPO 浓度升高，但 AcI 患者和对照组的血清 EPO 浓度没有升高。仅在 ACD/IDA、AcI 和对照组中观察到铁调素与 IL-6 水平之间存在正相关。在对照组中，铁调素与铁蛋白之间呈显著正相关，而在 IDA 中，铁调素与铁蛋白之间呈显著负相关。在 ACD/IDA 和 IDA 组中，铁调素表达与网织红细胞计数之间的显著负相关尤为明显。所有这些数据表明，铁调素可能在 ACD、ACD/IDA 和 IDA 的发病机制中发挥作用，它可能是这些贫血检测和鉴别诊断的潜在标志物。
