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Cell. 2018 Aug 23;174(5):1229-1246.e17. doi: 10.1016/j.cell.2018.07.007. Epub 2018 Aug 2.
4
Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.毛细胞利用具有不同Ca2+内流电压依赖性的活性区将声音分解为互补的神经编码。
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4716-25. doi: 10.1073/pnas.1605737113. Epub 2016 Jul 26.
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Basic response properties of auditory nerve fibers: a review.听觉神经纤维的基本反应特性：综述
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An optimized fluorescent probe for visualizing glutamate neurotransmission.一种用于可视化谷氨酸能神经传递的优化荧光探针。
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Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses. ribbons 大小和 AMPA 受体表达的相反梯度是耳蜗神经/毛细胞突触敏感性差异的基础。
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Presynaptic calcium and control of vesicle fusion.突触前钙与囊泡融合的调控
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Single-neuron labeling in the cat auditory nerve.猫听觉神经中的单神经元标记
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Auditory-nerve response from cats raised in a low-noise chamber.在低噪声环境中饲养的猫的听觉神经反应。
J Acoust Soc Am. 1978 Feb;63(2):442-55. doi: 10.1121/1.381736.

分而治之，征服声音多样性。

Divide and conquer acoustic diversity.

机构信息

Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, CA Buenos Aires, Argentina.

Instituto de Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres" (CONICET), CA Buenos Aires, Argentina.

出版信息

EMBO J. 2021 Mar 1;40(5):e107531. doi: 10.15252/embj.2020107531. Epub 2021 Feb 8.

DOI:10.15252/embj.2020107531
PMID:33555064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7917547/
Abstract

Humans can recognize differences in sound intensity of up to 6 orders of magnitude. However, it is not clear how this is achieved and what enables our auditory systems to encode such a gradient. Özçete & Moser (2021) report in this issue that the key to this lies in the synaptic heterogeneity within individual sensory cells in the inner ear.

摘要

人类可以识别高达 6 个数量级的声音强度差异。然而，目前尚不清楚这是如何实现的，以及我们的听觉系统如何对这种梯度进行编码。Özçete 和 Moser（2021）在本期杂志中报道，关键在于内耳单个感觉细胞内的突触异质性。