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人血清淀粉样蛋白A蛋白三种异构体模式的鉴定

Identification of three isoform patterns of human serum amyloid A protein.

作者信息

Strachan A F, de Beer F C, van der Westhuyzen D R, Coetzee G A

机构信息

Department of Internal Medicine, University of Stellenbosch Medical School, Tygerberg, South Africa.

出版信息

Biochem J. 1988 Feb 15;250(1):203-7. doi: 10.1042/bj2500203.

DOI:10.1042/bj2500203
PMID:3355511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148833/
Abstract

Three patterns of human apo-SAA (serum amyloid A protein) isoforms have been identified by electrofocusing. In pattern 1, six major apo-SAA isoforms of pI 6.0, 6.4, 7.0, 7.4, 7.5 and 8.0 were found. In pattern 2, the apo-SAA isoforms of pI 7.4 and 8.0 were not detected, whereas in pattern 3 the pI-7.0 and -7.5 isoforms were lacking. Six patients displayed apo-SAA isoform pattern 1, 11 displayed pattern 2 and one displayed pattern 3.

摘要

通过电聚焦已鉴定出三种人类载脂蛋白 SAA（血清淀粉样蛋白 A）亚型模式。在模式 1 中，发现了六种主要的载脂蛋白 SAA 亚型，其等电点分别为 6.0、6.4、7.0、7.4、7.5 和 8.0。在模式 2 中，未检测到等电点为 7.4 和 8.0 的载脂蛋白 SAA 亚型，而在模式 3 中，缺少等电点为 7.0 和 7.5 的亚型。六名患者表现出载脂蛋白 SAA 亚型模式 1，11 名表现出模式 2，一名表现出模式 3。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/00d560a59124/biochemj00237-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/01043acd31a6/biochemj00237-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/1133c4cb4523/biochemj00237-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/00d560a59124/biochemj00237-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/01043acd31a6/biochemj00237-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/1133c4cb4523/biochemj00237-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76e3/1148833/00d560a59124/biochemj00237-0205-a.jpg

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本文引用的文献

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Expression of recombinant human serum amyloid A in mammalian cells and demonstration of the region necessary for high-density lipoprotein binding and amyloid fibril formation by site-directed mutagenesis.重组人血清淀粉样蛋白A在哺乳动物细胞中的表达以及通过定点诱变对高密度脂蛋白结合和淀粉样纤维形成所需区域的证明。
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Characterization of the inbred CE/J mouse strain as amyloid resistant.近交系CE/J小鼠品系抗淀粉样蛋白特性的研究
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9
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10
Human serum amyloid A protein. Behaviour in aqueous and urea-containing solutions and antibody production.人血清淀粉样蛋白A。在水溶液和含尿素溶液中的行为及抗体产生。
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