Maury C P, Ehnholm C, Lukka M
Ann Rheum Dis. 1985 Oct;44(10):711-5. doi: 10.1136/ard.44.10.711.
Serum amyloid A (SAA), a polymorphic high density lipoprotein associated plasma protein, is the putative circulating precursor of tissue AA protein fibrils in reactive (secondary) amyloidosis. In the present study we examined the SAA subtype pattern in various acute and chronic inflammatory states in order to find out whether disease-specific SAA isoform profiles exist. The method used to study the subtype pattern is based on electrofocusing of serum followed by immunoblotting. Our results show that the SAA subtype pattern is similar in patients with rheumatoid arthritis with or without amyloid. In addition, in amyloidotic subjects the SAA subtype response to acute tissue injury (arthroplasty) did not differ from that in patients without amyloidosis. Analysis of patients with acute and chronic infectious diseases and non-rheumatic inflammatory conditions showed similar SAA patterns in all subjects. These results suggest that the SAA subtype response to tissue injury and inflammation is similar irrespective of the initiating stimulus.
血清淀粉样蛋白A（SAA）是一种多态性高密度脂蛋白相关血浆蛋白，是反应性（继发性）淀粉样变性中组织AA蛋白原纤维的假定循环前体。在本研究中，我们检测了各种急性和慢性炎症状态下的SAA亚型模式，以确定是否存在疾病特异性的SAA同工型谱。用于研究亚型模式的方法基于血清的等电聚焦，随后进行免疫印迹。我们的结果表明，有或没有淀粉样变的类风湿性关节炎患者的SAA亚型模式相似。此外，在淀粉样变性患者中，SAA对急性组织损伤（关节成形术）的亚型反应与无淀粉样变性的患者没有差异。对急性和慢性传染病以及非风湿性炎症患者的分析表明，所有受试者的SAA模式相似。这些结果表明，无论起始刺激如何，SAA对组织损伤和炎症的亚型反应都是相似的。
