Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Duke Global Health Institute, Duke University, Durham, North Carolina 27708, United States.
Environ Sci Technol. 2021 Mar 2;55(5):3101-3111. doi: 10.1021/acs.est.0c06114. Epub 2021 Feb 8.
Fine particulate matter (PM) with a higher oxidative potential has been thought to be more detrimental to pulmonary health. We aim to investigate the associations between personal exposure to PM oxidative potential and pulmonary outcomes in asthmatic children. We measured each of the 43 asthmatic children 4 times for airway mechanics, lung function, airway inflammation, and asthma symptom scores. Coupling measured indoor and outdoor concentrations of PM mass, constituents, and oxidative potential with individual time-activity data, we calculated 24 h average personal exposures 0-3 days prior to a health outcome measurement. We found that increases in daily personal exposure to PM oxidative potential were significantly associated with increased small, large, and total airway resistance, increased airway impedance, decreased lung function, and worsened scores of individual asthma symptoms and the total symptom score. Among the PM constituents, organic matters largely of indoor origin contributed the greatest to PM oxidative potential. Given that the variability in PM oxidative potential was a stronger driver than PM mass for the variability in the respiratory health outcomes, it is suggested to reduce PM oxidative potential, particularly by reducing the organic matter constituent of indoor PM, as a targeted source control strategy in asthma management.
细颗粒物（PM）具有更高的氧化潜力，被认为对肺部健康更有害。我们旨在研究哮喘儿童个体暴露于 PM 氧化潜力与肺部结果之间的关联。我们对 43 名哮喘儿童进行了 4 次气道力学、肺功能、气道炎症和哮喘症状评分的测量。将 PM 质量、成分和氧化潜力的测量室内和室外浓度与个体时间活动数据相结合，我们计算了健康结果测量前 0-3 天的 24 小时平均个体暴露量。我们发现，每日个体暴露于 PM 氧化潜力的增加与小气道、大气道和总气道阻力的增加、气道阻抗的降低、肺功能的降低以及个体哮喘症状和总症状评分的恶化显著相关。在 PM 成分中，主要来自室内的有机物质对 PM 氧化潜力的贡献最大。鉴于 PM 氧化潜力的变异性比 PM 质量对呼吸健康结果的变异性更强，建议减少 PM 氧化潜力，特别是通过减少室内 PM 的有机物质成分，作为哮喘管理的有针对性的源头控制策略。
