Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France.
Agence de l'environnement et de la Maîtrise de l'Energie, Angers, France.
Environ Health Perspect. 2023 Jan;131(1):17004. doi: 10.1289/EHP11155. Epub 2023 Jan 25.
Fine particulate matter () has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal oxidative potential (OP) on lung function in infants and preschool children.
We estimated the associations of personal exposure to and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.
We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout () test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal mass and OP with lung function parameters were estimated using multiple linear regressions.
In neonates, an interquartile (IQR) increase in () was associated with a decrease in functional residual capacity (FRC) measured by [; 95% confidence interval (CI): , 0.15]. Associations with showed similar patterns in comparison with but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs () from AOS tended to be associated with higher (; 95% CI: , 0.24) and (; ; 95% CI: , 0.27) but not with (; ; 95% CI: , 0.16). Results for FRC and remained similar in OP models adjusted on .
Prenatal exposure to was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155.
细颗粒物（）已被发现对儿童的呼吸道健康有害，但很少有研究调查孕妇产前氧化潜能（OP）对婴儿和学龄前儿童肺功能的影响。
我们估计孕妇个人接触和 OP 与后代客观肺功能参数之间的关联，并比较这两种暴露指标之间关联的强度。
我们使用了来自 SEPAGES 队列的 356 对母婴数据。在一周内收集两次 PM 过滤器，并使用二硫苏糖醇（DTT）和抗坏血酸（AA）测定法分析 OP，定量每个孕妇的暴露量。使用潮气呼吸分析（TBFVL）和氮多次呼吸冲洗（）试验在 6 周时进行肺功能评估，并在 3 岁时使用空气波振荡测量法（AOS）进行肺功能评估。使用多元线性回归估计产前质量和 OP 与肺功能参数的关联。
在新生儿中，（）的四分位距（IQR）增加与通过（测量的功能残气量（FRC）减少有关 [; 95%置信区间（CI）：，0.15]。与相比，与的关联具有相似的模式，但幅度较小。肺清除指数（LCI）和 TBFVL 参数与所考虑的暴露没有任何明显的关联。在 3 岁时，AOS 中肺频率依赖性阻力（）的增加趋势与更高的（；95%CI：，0.24）和（；；95%CI：，0.27）相关，但与（；；95%CI：，0.16）无关。在调整后的 OP 模型中，FRC 和的结果仍然相似。
产前接触与随时间推移的几个后代肺功能参数相关，这些参数都与肺容积有关。https://doi.org/10.1289/EHP11155.
