Department of Chemistry, Rice University, 7530 Main Street, 77030, Houston, TX, 77005, United States; IdISBA - Fundación de Investigación Sanitaria de las Islas Baleares, Palma, Spain.
Independent Science Writer, Kolkata, India.
Ageing Res Rev. 2021 May;67:101268. doi: 10.1016/j.arr.2021.101268. Epub 2021 Feb 5.
The epidemic of obesity is a major challenge for health policymakers due to its far-reaching effects on population health and potentially overwhelming financial burden on healthcare systems. Obesity is associated with an increased risk of developing acute and chronic diseases, including hypertension, stroke, myocardial infarction, cardiovascular disease, diabetes, and cancer. Interestingly, the metabolic dysregulation associated with obesity is similar to that observed in normal aging, and substantial evidence suggests the potential of obesity to accelerate aging. Therefore, understanding the mechanism of fat tissue dysfunction in obesity could provide insights into the processes that contribute to the metabolic dysfunction associated with the aging process. Here, we review the molecular and cellular mechanisms underlying both obesity and aging, and how obesity and aging can predispose individuals to chronic health complications. The potential of lifestyle and pharmacological interventions to counter obesity and obesity-related pathologies, as well as aging, is also addressed.
肥胖症的流行是卫生政策制定者面临的一个主要挑战，因为它对人口健康有着深远的影响，并可能给医疗保健系统带来难以承受的财政负担。肥胖与多种急性和慢性疾病的风险增加有关，包括高血压、中风、心肌梗死、心血管疾病、糖尿病和癌症。有趣的是，与肥胖相关的代谢失调与正常衰老时观察到的情况相似，大量证据表明肥胖有可能加速衰老。因此，了解肥胖症中脂肪组织功能障碍的机制可以深入了解导致与衰老过程相关的代谢功能障碍的过程。在这里，我们综述了肥胖症和衰老的分子和细胞机制，以及肥胖症和衰老如何使个体易患慢性健康并发症。还讨论了生活方式和药物干预在对抗肥胖症及其相关病理以及衰老方面的潜力。
