乙醇脱氢酶并非小鼠酒精偏好的主要决定因素。

Alcohol dehydrogenase is not a major determinant of alcohol preference in mice.

作者信息

Teichert-Kuliszewska K, Israel Y, Cinader B

机构信息

Department of Immunology, University of Toronto, Ontario, Canada.

出版信息

Alcohol. 1988 Jan-Feb;5(1):45-7. doi: 10.1016/0741-8329(88)90042-0.

DOI:10.1016/0741-8329(88)90042-0

PMID:3355668

Abstract

We present evidence that in MRL/Mp mice, difference in one gene affects the activity of alcohol dehydrogenase. MRL/Mp- + show high alcohol dehydrogenase (ADH) activity in the range of that found in C57BL/6, while MRL/Mp-lpr show ADH values in the range of non-drinker strains such as DBA/1, BALB/c, A, SJL, CBA and C3H/He. Voluntary alcohol consumption in MRL/Mp- + is 30-40% higher than that in the MRL/Mp-lpr. However, alcohol preference of both congenic strains is markedly lower than those of C57BL/6 mice. Our findings lead us to conclude that although alcohol dehydrogenase levels do relate to alcohol preference in mice, they are responsible for only a minor fraction of inter-strain differences.

摘要

我们提供的证据表明，在MRL/Mp小鼠中，一个基因的差异会影响酒精脱氢酶的活性。MRL/Mp- +小鼠的酒精脱氢酶（ADH）活性较高，与C57BL/6小鼠中的活性范围相当，而MRL/Mp-lpr小鼠的ADH值则处于非饮酒品系（如DBA/1、BALB/c、A、SJL、CBA和C3H/He）的范围内。MRL/Mp- +小鼠的自愿酒精摄入量比MRL/Mp-lpr小鼠高30%-40%。然而，这两种同源品系的酒精偏好均明显低于C57BL/6小鼠。我们的研究结果使我们得出结论，虽然酒精脱氢酶水平确实与小鼠的酒精偏好有关，但它们仅导致品系间差异的一小部分。