The University of Queensland, School of Veterinary Science, Gatton, Queensland, 4343, Australia; Centre for Children's Health Research, Queensland Paediatric Infectious Disease Laboratory, Lady Cilento Research Precinct, South Brisbane, Queensland, 4101, Australia.
The University of Queensland, School of Veterinary Science, Gatton, Queensland, 4343, Australia.
Prev Vet Med. 2021 Apr;189:105282. doi: 10.1016/j.prevetmed.2021.105282. Epub 2021 Jan 28.
Q fever is a zoonotic disease caused by infection with Coxiella burnetii transmitted from animals including, but not limited to, cattle, sheep and goats. The infection in cattle is typically sub-clinical with some evidence suggesting associated reproductive loss. There is currently limited data on the true prevalence and distribution of coxiellosis in beef cattle across northern Australia. During this study, 2,012 sera samples from beef cattle managed on commercial farms located in Queensland and the Northern Territory were tested using an indirect immunofluorescent assay (IFA) for serological evidence of IgG antibodies against C. burnetii. Bayesian latent class models were used to estimate the true prevalence, adjusted for diagnostic test sensitivity and specificity and incorporating the hierarchical structure of the cattle within farms and regions. In this study, cattle in the Northern Territory had lower estimated true prevalence than cattle within most regions of Queensland with the exception of south-east Queensland. Results from this study have described the geographic distribution and estimated the true prevalence of antibodies to C. burnetii in a sample of extensively managed beef cattle located across the tropical grazing regions of northern Australia.
Q 热是一种由科氏立克次体感染引起的动物源性疾病，可通过包括牛、羊和山羊在内的动物传播。牛的感染通常是亚临床的，有一些证据表明与生殖损失有关。目前，关于澳大利亚北部肉牛中柯克斯氏体病的真实流行率和分布情况的数据有限。在这项研究中，使用间接免疫荧光检测法（IFA）对来自昆士兰州和北领地商业农场管理的 2012 份肉牛血清样本进行了检测，以检测针对 C. burnetii 的 IgG 抗体的血清学证据。贝叶斯潜在类别模型用于估计真实流行率，同时调整了诊断测试的敏感性和特异性，并考虑了农场和地区内牛的层次结构。在这项研究中，北领地的牛的估计真实流行率低于昆士兰州大多数地区的牛，除了昆士兰州东南部。本研究的结果描述了在澳大利亚北部热带放牧地区广泛管理的肉牛样本中，针对 C. burnetii 的抗体的地理分布和估计真实流行率。
