State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Biomed Pharmacother. 2021 May;137:111326. doi: 10.1016/j.biopha.2021.111326. Epub 2021 Feb 5.
Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.
近年来，非酒精性脂肪性肝病（NAFLD）的患病率逐年上升；然而，由于其发病机制复杂，目前尚无有效的治疗方法。据报道，细胞色素 P450 2E1（CYP2E1）在 NAFLD 的发展中起着不可或缺的作用，大量研究表明，类黄酮具有保肝作用，并通过调节 CYP2E1 的活性对 NAFLD 发挥有益作用。因此，类黄酮类化合物将来可能成为治疗 NAFLD 的有效药物。这促使我们回顾了 NAFLD 的病理机制研究进展和病理过程中 CYP2E1 活性变化的影响，并总结了类黄酮对 CYP2E1 活性的保护作用。
