FSPE Applied Bioenergetics Lab, University of Novi Sad, 21000 Novi Sad, Serbia.
Faculty of Health Sciences, University of Pecs, H-7621 Pecs, Hungary.
Nutrients. 2021 Feb 4;13(2):503. doi: 10.3390/nu13020503.
Post-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabolism, perturbing either tissue levels of creatine in the brain, the rates of phosphocreatine resynthesis in the skeletal muscle, or the concentrations of the enzyme creatine kinase in the blood. Furthermore, supplemental creatine and related guanidino compounds appear to impact both patient- and clinician-reported outcomes in syndromes and maladies with chronic fatigue. This paper critically overviews the most common disturbances in creatine metabolism in various PVFS populations, summarizes human trials on dietary creatine and creatine analogs in the syndrome, and discusses new frontiers and open questions for using creatine in a post-COVID-19 world.
病毒性疲劳综合征 (PVFS) 是一种广泛存在的慢性神经系统疾病，其病因不明确，也没有确切的诊断测试，更没有经过批准的药物治疗、疗法或治愈方法。除此之外，PVFS 还可能伴有肌酸代谢的各种异常，影响大脑中的肌酸组织水平、骨骼肌中磷酸肌酸的再合成速率，或血液中的肌酸激酶浓度。此外，补充肌酸和相关胍基化合物似乎对具有慢性疲劳的综合征和疾病的患者和临床医生报告的结果都有影响。本文批判性地综述了各种 PVFS 人群中肌酸代谢的最常见异常，总结了该综合征中饮食肌酸和肌酸类似物的人体试验，并讨论了在后 COVID-19 世界中使用肌酸的新前沿和未解决的问题。
