dl-α-生育酚烟酸酯治疗振动病的双盲对照试验

Comparative double-blind trial of dl-alpha-tocopheryl nicotinate on vibration disease.

作者信息

Matoba T, Kusumoto H, Mizuki Y, Yamada K

出版信息

Tohoku J Exp Med. 1977 Sep;123(1):67-75. doi: 10.1620/tjem.123.67.

DOI:10.1620/tjem.123.67

Abstract

Sixty inpatients with vibration disease were examined on the effect of dl-alpha-tocopheryl nicotinate by comparative double-blind study. The observed period was 6 weeks and the dose was 6 capsules a day (600 mg as dl-alpha-tocopheryl nicotinate, Juvela Nicotinate, referred to as EN). The physical exercise therapy was applied to all patients throughout the test period. EN group became better with a significant difference from P (placebo) group in the subjective symptoms, the clinical examinations and the collective improving rate (p less than 0.01, 0.05, 0.01), respectively. The improvement of the subjective symptoms of both groups was higher 6 weeks than 3 weeks after administration. Most items in EN group became better significantly (p less than 0.05) as compared with those in P group. The examinations of the peripheral functions in EN group showed a significant improvement 6 weeks after administration in comparison with those in P group. Blood chemistry, blood cell counts and serum electrolytes changed within normal range. Thus, this preparation would be a curative agent for patients with vibration disease.

摘要

通过比较双盲研究，对60例振动病住院患者进行了dl-生育酚烟酸酯疗效观察。观察期为6周，剂量为每日6粒胶囊（相当于600mg dl-生育酚烟酸酯，商品名Juvela Nicotinate，简称EN）。在整个试验期间，所有患者均接受体育锻炼治疗。EN组在主观症状、临床检查及总体改善率方面均有改善，与P（安慰剂）组相比有显著差异（分别为p<0.01、0.05、0.01）。两组主观症状的改善在给药6周时均高于给药3周时。与P组相比，EN组的大多数项目均有显著改善（p<0.05）。与P组相比，EN组给药6周后外周功能检查有显著改善。血液化学、血细胞计数及血清电解质均在正常范围内变化。因此，该制剂对振动病患者可能是一种治疗药物。