Hidiroglou N, McDowell L R, Papas A M, Antapli M, Wilkinson N S
Department of Surgery, East Tennessee State University, Johnson City 37604.
J Anim Sci. 1992 Aug;70(8):2556-61. doi: 10.2527/1992.7082556x.
A study was carried out to assess the bioavailabilities of several forms of vitamin E in lambs. A total of 40 lambs was allotted to eight dietary groups of five each and supplemented or not daily for 60 d with equimolar amounts of different vitamin E compounds as follows: 1) control, no supplemental vitamin E, 2) DL-alpha-tocopheryl acetate, 3) D-alpha-tocopheryl acetate, 4), D-alpha-tocopheryl succinate, 5) D-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS), 6) DL-alpha-tocopheryl nicotinate, 7) DL-alpha-tocopheryl nicotinate+ TPGS, or 8) D-alpha-tocopheryl acetate + TPGS. During these 60 d, serum alpha-tocopherol concentrations in the control lambs remained constant and lower (P less than .05) than in lambs that received all treatments. Various indices of bioavailability, including Cmax-C(i) (concentration maximum-concentration initial), Ct-C(i) (concentration terminal-concentration initial), areas under the serum concentrations profiles, and pooled increment were higher (P less than .05) with D-alpha-tocopheryl acetate+ TPGS than in the other groups, suggesting a synergism between these forms. No such effect was observed between nicotinate and TPGS. For the TPGS, a water-soluble form of vitamin E, the indices of bioavailability were lower (P less than .05) than for the other groups. D-alpha-tocopheryl acetate resulted in a bioavailability that outranked all the other forms of vitamin E, except those of D-alpha-tocopheryl acetate + TPGS. A slightly higher bioavailability index was observed for D-alpha-tocopheryl succinate than for DL-alpha-tocopheryl nicotinate.(ABSTRACT TRUNCATED AT 250 WORDS)
开展了一项研究，以评估几种形式的维生素E在羔羊体内的生物利用度。总共40只羔羊被分配到8个日粮组，每组5只，每天补充或不补充等摩尔量的不同维生素E化合物，持续60天，具体如下：1）对照组，不补充维生素E；2）DL-α-生育酚醋酸酯；3）D-α-生育酚醋酸酯；4）D-α-生育酚琥珀酸酯；5）D-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）；6）DL-α-生育酚烟酸酯；7）DL-α-生育酚烟酸酯 + TPGS；或8）D-α-生育酚醋酸酯 + TPGS。在这60天期间，对照组羔羊的血清α-生育酚浓度保持恒定，且低于（P < 0.05）接受所有处理的羔羊。包括Cmax-C(i)（最大浓度 - 初始浓度）、Ct-C(i)（终末浓度 - 初始浓度）、血清浓度曲线下面积和合并增量在内的各种生物利用度指标，D-α-生育酚醋酸酯 + TPGS组高于（P < 0.05）其他组，表明这些形式之间存在协同作用。在烟酸酯和TPGS之间未观察到这种效应。对于水溶性维生素E形式的TPGS，其生物利用度指标低于（P < 0.05）其他组。D-α-生育酚醋酸酯的生物利用度高于所有其他形式的维生素E，但D-α-生育酚醋酸酯 + TPGS除外。观察到D-α-生育酚琥珀酸酯的生物利用度指标略高于DL-α-生育酚烟酸酯。（摘要截断于250字）
