Kim Sunmi, Seo Myungwon, Na Minju, Kim Jongwoon
Chemical Safety Research Center, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.
Toxics. 2021 Feb 4;9(2):32. doi: 10.3390/toxics9020032.
Global regulations of biocides have been continuously enhanced for protecting human health and the environment from potentially harmful biocidal products. Such regulations consider the combined toxicity caused by mixture components in a biocidal product of which approval and authorization are to be enhanced. Although the combined exposure scenarios of components in mixtures are firstly needed to conduct the mixture risk assessment, systematic combined exposure scenarios are still lacking. In this study, combined inhalation exposure scenarios of biocides in household chemical and biocidal products marketed in South Korea were investigated based on the European Union (EU) and Korean chemical product databases and various data sources integration. The information of 1058 biocidal products and 675 household chemical products that are likely to cause inhalation exposure with two or more biocides was collected, and mixture combination patterns were investigated. Binary mixtures occupied 72% in biocidal products. The most frequently appearing binary mixture was phthalthrin and d-phenothrin. Based on the frequency of use, we suggested a priority list of biocide mixture combinations which need to be firstly evaluated for identifying their combined toxicity for the mixture risk assessment. This study highlights that the derived combined inhalation exposure scenarios can support and facilitate further studies on priority settings for mixture risk assessment and management of potentially inhalable biocides.
为保护人类健康和环境免受潜在有害杀生物剂产品的影响，全球对杀生物剂的监管一直在不断加强。此类监管考虑了杀生物剂产品中混合物成分所造成的联合毒性，而对杀生物剂产品的批准和授权将得到加强。尽管首先需要混合物中各成分的联合暴露情景来进行混合物风险评估，但系统的联合暴露情景仍然缺乏。在本研究中，基于欧盟（EU）和韩国的化学品数据库以及各种数据源整合，对韩国市场上销售的家用化学品和杀生物剂产品中杀生物剂的联合吸入暴露情景进行了调查。收集了1058种可能导致两种或更多种杀生物剂吸入暴露的杀生物剂产品和675种家用化学品的信息，并对混合物组合模式进行了研究。二元混合物在杀生物剂产品中占72%。最常出现的二元混合物是邻苯二甲酸菊酯和右旋苯醚菊酯。基于使用频率，我们提出了一份杀生物剂混合物组合的优先清单，为识别混合物风险评估中的联合毒性，需要首先对其进行评估。本研究强调，所推导的联合吸入暴露情景可为进一步研究潜在可吸入杀生物剂的混合物风险评估和管理的优先级设置提供支持并便利相关研究。
