正常妊娠中的糖化白蛋白和糖化血红蛋白水平

Glycated albumin and glycated hemoglobin levels in normal pregnancy.

作者信息

Rai K B, Kumar A, Pattabiraman T N

机构信息

Department of Biochemistry, Kasturba Medical College, Karnataka, India.

出版信息

Biochem Med Metab Biol. 1988 Feb;39(1):5-10. doi: 10.1016/0885-4505(88)90051-5.

DOI:10.1016/0885-4505(88)90051-5

PMID:3355715

Abstract

Glycated albumin levels showed a progressive increase during normal pregnancy. The mean values (mole hexose/mole protein) were 1.68 +/- 0.27 (n = 15) in nonpregnant women, 1.83 +/- 0.21 (n = 11) in first trimester, 2.00 +/- 0.41 (n = 13) in second trimester, and 2.42 +/- 0.49 (n = 15) in third trimester. Glycated hemoglobin levels indicated a biphase pattern with low values at midpregnancy (controls 0.29 +/- 0.05, first trimester 0.30 +/- 0.04, second trimester 0.27 +/- 0.05, and third trimester 0.33 +/- 0.04). The data suggest that glycated albumin reflects the decreased glucose tolerance in pregnancy better that glycated hemoglobin levels. The reasons for the differing pattern of the two glycated proteins are discussed.

摘要

糖化白蛋白水平在正常妊娠期间呈逐渐上升趋势。非妊娠女性的平均值（摩尔己糖/摩尔蛋白质）为1.68±0.27（n = 15），孕早期为1.83±0.21（n = 11），孕中期为2.00±0.41（n = 13），孕晚期为2.42±0.49（n = 15）。糖化血红蛋白水平呈现双相模式，在妊娠中期值较低（对照组0.29±0.05，孕早期0.30±0.04，孕中期0.27±0.05，孕晚期0.33±0.04）。数据表明，糖化白蛋白比糖化血红蛋白水平能更好地反映妊娠期间葡萄糖耐量的降低。文中讨论了两种糖化蛋白模式不同的原因。