School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Int J Environ Res Public Health. 2021 Feb 4;18(4):1494. doi: 10.3390/ijerph18041494.
XAB2 protein (xeroderma pigmentosum group A-binding protein 2) plays a significant role in the nucleotide excision repair pathway. Polymorphisms in the XAB2 gene may have an effect on the capability of DNA repair and further contribute to the risk of developing various cancers. In order to investigate the relationship between XAB2 genetic variants and the risk of gastric cancer, we performed a hospital-based case-control study. XAB2 tagSNPs were selected and then genotyped by iPlex Gold Genotyping Assay and Sequenom MassArray. By performing logistic regression analysis, odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association of XAB2 tagSNPs with the risk of gastric cancer. Our results showed that XAB2 rs794078AA genotype was associated with a significantly lower risk of gastric cancer compared with GG genotype with OR (95% CI) of 0.33 (0.12-0.91). Stratified analysis indicated a significantly decreased risk for gastric cancer among smokers with rs794078AA genotype compared with nonsmokers with GG genotype (OR = 0.11, 95% CI = 0.01-0.91, = 0.040). The gene-gene interactions by multifactor dimensionality reduction (MDR) showed that tagSNP rs794078 was the best predictive element for gastric cancers (Testing Bal. Acc = 51.68%, = 0.055, cross-validation consistency = 9). Therefore, the XAB2 tagSNP rs794078 may play an important role in the development of gastric cancer.
XAB2 蛋白（着色性干皮病 A 结合蛋白 2）在核苷酸切除修复途径中发挥重要作用。XAB2 基因的多态性可能会影响 DNA 修复能力，并进一步增加罹患各种癌症的风险。为了研究 XAB2 遗传变异与胃癌风险之间的关系，我们进行了一项基于医院的病例对照研究。选择 XAB2 标签 SNP 后，采用 iPlex Gold Genotyping Assay 和 Sequenom MassArray 进行基因分型。通过逻辑回归分析，使用比值比（OR）和 95%置信区间（CI）来估计 XAB2 标签 SNP 与胃癌风险之间的关联。我们的结果表明，与 GG 基因型相比，XAB2 rs794078AA 基因型与胃癌的风险显著降低，OR（95%CI）为 0.33（0.12-0.91）。分层分析表明，与 GG 基因型的非吸烟者相比，rs794078AA 基因型的吸烟者患胃癌的风险显著降低（OR = 0.11，95%CI = 0.01-0.91， = 0.040）。多因素维度缩减（MDR）的基因-基因相互作用表明，标签 SNP rs794078 是预测胃癌的最佳预测因素（检测平衡准确率 = 51.68%， = 0.055，交叉验证一致性 = 9）。因此，XAB2 标签 SNP rs794078 可能在胃癌的发生发展中起重要作用。
