Majlesara Ali, Krause Jürgen, Khajeh Elias, Ghamarnejad Omid, Gharabaghi Negin, Tinoush Parham, Mohammadi Sara, Al-Saeedi Mohammed, Mehrabi Arianeb, Golriz Mohammad
Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
J Int Med Res. 2021 Feb;49(2):300060521990219. doi: 10.1177/0300060521990219.
Despite the recent advances in surgical techniques and perioperative care, liver resection (especially extended hepatectomy) is still a high-risk procedure with considerable morbidity and mortality. Experimental large animal models are the best option for studies in this regard. The present study was performed to present an easy-to-learn, fast, and multipurpose model of liver resection in a porcine model.
Stepwise liver resections (resection of segments II/III, IVa/IVb, and VIII/IV) were performed in eight pigs with intraoperative monitoring of hemodynamic parameters. The technical aspects, tips, and tricks of this method are explained in detail.
Based on the specific anatomical characteristics of the porcine liver, all resection types including segmental resection, hemihepatectomy, and extended hepatectomy could be performed in one animal in an easy-to-learn and fast technique. All animals were hemodynamically stable following stepwise liver resection.
Stepwise liver resection using stapler in a porcine model is a fast and easy-to-learn method with which junior staff and research fellows can perform liver resection up to extended hepatectomy under stable conditions.
尽管近期手术技术和围手术期护理取得了进展，但肝切除术（尤其是扩大肝切除术）仍然是一种高风险手术，具有相当高的发病率和死亡率。实验性大型动物模型是这方面研究的最佳选择。本研究旨在介绍一种在猪模型中易于学习、快速且多功能的肝切除模型。
对八头猪进行逐步肝切除术（切除Ⅱ/Ⅲ段、Ⅳa/Ⅳb段和Ⅷ/Ⅳ段），术中监测血流动力学参数。详细解释了该方法的技术要点、技巧和窍门。
基于猪肝的特定解剖特征，所有切除类型，包括节段性切除、半肝切除和扩大肝切除，都可以在一只动物身上以易于学习和快速的技术进行。逐步肝切除术后所有动物的血流动力学均稳定。
在猪模型中使用吻合器进行逐步肝切除术是一种快速且易于学习的方法，初级工作人员和研究员可以在稳定条件下进行直至扩大肝切除术的肝切除。
