Department of Cognitive Science, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Department of Speech Pathology, South East Sydney Local Health District, Uniting War Memorial Hospital, Sydney, Australia.
Neuropsychol Rehabil. 2022 Jul;32(6):1121-1163. doi: 10.1080/09602011.2021.1879174. Epub 2021 Feb 8.
Evidence of generalization to connected speech following lexical retrieval treatment in Primary Progressive Aphasia (PPA) is scarce. Consequently, this study systematically investigated changes in verb phrase production following lexical retrieval treatment in a series of single case experimental design studies. Four individuals with PPA (three semantic- and one logopenic variant PPA) who had previously demonstrated that they could integrate verbs and nouns into sentence structures in a cueing paradigm, undertook a sequence of verb and noun lexical retrieval treatments using Repetition and Reading in the Presence of a Picture. Production of treated nouns- and/or verbs-in-isolation significantly improved following treatment for three of the four participants. Verb phrase production did not improve for one of these participants (logopenic PPA), perhaps due to the relatively small treatment dose. Two participants (semantic variant PPA) did, however, demonstrate across-level generalization, with improvement in treated verbs and using those verbs in (untreated) verb phrases. Their verb phrase production improved most after lexical retrieval treatment for both nouns and verbs, suggesting this combined approach may benefit across-level generalization for some individuals in clinical practice.
在原发性进行性失语症（PPA）中，词汇检索治疗后向连接言语的泛化证据很少。因此，本研究系统地调查了在一系列单病例实验设计研究中，词汇检索治疗后动词短语产生的变化。四个患有 PPA 的个体（三个语义变体和一个命名性失语变体）之前已经证明他们可以在提示范式中整合动词和名词来构成句子结构，他们使用图片呈现的重复和阅读进行了一系列动词和名词词汇检索治疗。治疗后，有三个参与者的治疗名词和/或动词的孤立产生显著改善。但是，有一名参与者（命名性失语变体）的动词短语产生没有改善，可能是因为治疗剂量相对较小。然而，有两名参与者（语义变体 PPA）确实表现出跨层次的泛化，在（未治疗）动词短语中使用治疗动词和治疗动词。他们的动词短语产生在词汇检索治疗后对名词和动词都有最大的改善，这表明这种联合方法可能对一些临床实践中的个体有跨层次的泛化益处。
