V.N. Orekhovich Institute of Biomedical Chemistry, 10, Pogodinskaya Street, 119435 Moscow,Russian Federation.
V.N. Orekhovich Institute of Biomedical Chemistry, 10, Pogodinskaya street, 119435 Moscow,Russian Federation.
Curr Med Chem. 2021;28(40):8416-8432. doi: 10.2174/0929867328666210208113919.
This mini-review focuses on the investigation of novel nitrogen-containing steroid derivatives that are potentially applicable for prostate cancer treatment. It covers the literature of the last decade, highlighting the structure of new steroid compounds that exhibit significant activity in prostate cancer cells and possess pharmacological potency. New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen-containing heterocycles, and some related steroid-derived compounds are discussed in the review.
这篇小型综述专注于研究新型含氮甾体衍生物，这些衍生物可能适用于前列腺癌的治疗。它涵盖了过去十年的文献，重点介绍了在前列腺癌细胞中表现出显著活性并具有药理效力的新型甾体化合物的结构。本综述讨论了已知抗前列腺癌药物阿比特龙和加榴他滨的新型衍生物、用含氮杂环修饰的雄烷和孕烷的新型衍生物，以及一些相关的甾体衍生化合物。
